| Properties | Information | |
|---|---|---|
| PhytoCAT-ID | PhytoCAT-326 | |
| Phytochemical name or plant extracts | Pachystermine B | |
| PMID | 22804108 | |
| Literature evidence | The aim of the present study was to identify potentially useful natural compounds for the development of novel therapeutic agents to inhibit metastasis. | |
| IUPAC name | (3R)-1-[(3S,4R,5R,8S,9S,10R,13S,14S,17S)-17-[(1S)-1-(dimethylamino)ethyl]-4-hydroxy-10,13-dimethyl-2,3,4,5,6,7,8,9,11,12,14,15,16,17-tetradecahydro-1H-cyclopenta[a]phenanthren-3-yl]-3-propan-2-ylazetidin-2-one | |
| Phytochemicals’ class or type of plant extracts | Alkaloid | |
| Source of phytochemicals or plant Extracts | Pachysandra terminalis | |
| Geographical availability | China North-Central, China South-Central, China Southeast, Japan, Sakhalin | |
| Plant parts | Whole plant | |
| Other cancers | Breast cancer | |
| Target gene or protein | Epithelial growth factor | |
| Gene or Protein evidence | Compounds 1-5 and 8-14 inhibited the migration of MB-MDA-231 breast cancer cells induced by the chemokine epithelial growth factor. Compound 8 is Pachystermine B | |
| Target pathways | NA | |
| IC50 | 0.19 μM against MDA-MB-231 | |
| Potency | NA | |
| Cell line/ mice model | MDA-MB-231 | |
| Additional information | NA | |
| PubChem ID | NA | |
| Additional PMIDs | NA | |
| Additional sources of information | https://powo.science.kew.org/taxon/urn:lsid:ipni.org:names:353208-1 | |
| Safety | NA |