| Properties | Information | |
|---|---|---|
| PhytoCAT-ID | PhytoCAT-230 | |
| Phytochemical name or plant extracts | Papaverine | |
| PMID | 25980655 | |
| Literature evidence | Previous report of the vast effectiveness of opium derivatives in cancer therapy is leading us to see possible effects of these derivatives on cancer stem cells in order to find new agent for cancer therapy. | |
| IUPAC name | 1-[(3,4-dimethoxyphenyl)methyl]-6,7-dimethoxyisoquinoline | |
| Phytochemicals’ class or type of plant extracts | Alkaloid | |
| Source of phytochemicals or plant Extracts | Papaver rhoeas | |
| Geographical availability | Afghanistan, Albania, Algeria, Austria, Azores, Baleares, Baltic States, Belarus, Belgium, Bulgaria, Canary Is., Cape Verde, Central European Russia, Corse, Cyprus, Czechoslovakia, East Aegean Is., East European Russia, Egypt, France, Germany, Greece, Hungary, Iran, Iraq, Italy, Kazakhstan, Kriti, Krym, Lebanon-Syria, Libya, Madeira, Morocco, Netherlands, North Caucasus, Northwest European Russia, Pakistan, Palestine, Poland, Portugal, Romania, Sardegna, Saudi Arabia, Sicilia, Sinai, South European Russia, Spain, Switzerland, Transcaucasus, Tunisia, Turkey, Turkey-in-Europe, Turkmenistan, Ukraine, West Himalaya, Yugoslavia | |
| Plant parts | NA | |
| Other cancers | Breast cancer | |
| Target gene or protein | NA | |
| Gene or Protein evidence | NA | |
| Target pathways | NA | |
| IC50 | NA | |
| Potency | Papaverine has more cytotoxic effect on MCF-7 CSCs in comparison with parental cells, while CSCs population of MDA-MB-231 is more resistant to papaverine compared with MDA-MB-231 cells. | |
| Cell line/ mice model | MCF-7, MDA-MB-231 | |
| Additional information | This experiment suggests that noscapine and papaverine may be of use in cancer treatment due to their specific cytotoxicity and genotoxicity. | |
| PubChem ID | 4680 | |
| Additional PMIDs | 25890335 25980655 33233775 28479277 | |
| Additional sources of information | https://powo.science.kew.org/taxon/urn:lsid:ipni.org:names:306058-2 | |
| Safety | NA |