| Properties | Information | |
|---|---|---|
| PhytoCAT-ID | PhytoCAT-685 | |
| Phytochemical name or plant extracts | Noscapine | |
| PMID | 25980655 | |
| Literature evidence | Previous report of the vast effectiveness of opium derivatives in cancer therapy is leading us to see possible effects of these derivatives on cancer stem cells in order to find new agent for cancer therapy. | |
| IUPAC name | (3S)-6,7-dimethoxy-3-[(5R)-4-methoxy-6-methyl-7,8-dihydro-5H-[1,3]dioxolo[4,5-g]isoquinolin-5-yl]-3H-2-benzofuran-1-one | |
| Phytochemicals’ class or type of plant extracts | Benzylalkaloid | |
| Source of phytochemicals or plant Extracts | Papaver somniferum | |
| Geographical availability | Algeria, Baleares, Canary Is., Corse, France, Italy, Libya, Madeira, Morocco, Portugal, Sardegna, Sicilia, Spain, Tunisia | |
| Plant parts | Latex | |
| Other cancers | Breast cancer | |
| Target gene or protein | Bcl-xL, Bcl-2 | |
| Gene or Protein evidence | Our results showed that noscapine had lower toxicity in normal cells and was an effective anticancer agent that induced apoptosis in breast cancer cells because it increases Bax gene and protein expression in three cell lines, while decreases Bcl-xL gene expression, and Bcl-2 protein expression decreased in breast cancer cell lines. | |
| Target pathways | NA | |
| IC50 | 29 µM against MCF-7 69 µM against MDA-MB-231 | |
| Potency | Noscapine arrests MCF-7 and MDA-MB-231 CSCs cell cycle at G2/M phase | |
| Cell line/ mice model | MCF-7 and MDA-MB-231 | |
| Additional information | Noscapine enhanced the sensitivity of GL261 glioma tumors to radiation, resulting in a significant tumor growth delay. An antiangiogenic mechanism contributed to the effect. | |
| PubChem ID | 275196 | |
| Additional PMIDs | 24642711 30465924 33627059 33991960 34051055 34303039 34753081 32784088 27777381 31950839 21501599 24339417 25890335 23055449 25980655 27081867 27830833 34583618 34107169 34612529 27939522 | |
| Additional sources of information | https://powo.science.kew.org/taxon/urn:lsid:ipni.org:names:673724-1 | |
| Safety | NA |