| Properties | Information | |
|---|---|---|
| PhytoCAT-ID | PhytoCAT-721 | |
| Phytochemical name or plant extracts | Delcosine | |
| PMID | 31222559 | |
| Literature evidence | These acylated alkaloid derivatives caused accumulation of TNBC cells at sub-G1 within 24Â h. 1-Acylation of 1 appears to be critical for producing antiproliferative activity in this alkaloid class and a means to provide promising new leads for further development into antitumor agents. | |
| IUPAC name | (2R,3R,4S,5S,6S,8R,9R,10R,13S,16S,17R,18S)-11-ethyl-6,13,18-trimethoxy-11-azahexacyclo[7.7.2.1²,⁵.0¹,¹⁰.0³,⁸.0¹³,¹⁷]nonadecane-4,8,9,16-tetrol | |
| Phytochemicals’ class or type of plant extracts | Diterpenoid alkaloid | |
| Source of phytochemicals or plant Extracts | Aconitum barbatum Aconitum napellus Aconitum yesoense | |
| Geographical availability | Altay, Amur, Buryatiya, China North-Central, China Southeast, Chita, Inner Mongolia, Irkutsk, Kazakhstan, Khabarovsk, Korea, Krasnoyarsk, Manchuria, Mongolia, Tuva, West Siberia, Xinjiang, Yakutskiya ,,,,Most of Europe, including Britain, east to N. W. Asia and the Himalayas,,, Hokkaido, Japan | |
| Plant parts | Root | |
| Other cancers | Breast cancer, Lung cancer, Prostate cancer, Cervical cancer | |
| Target gene or protein | NA | |
| Gene or Protein evidence | NA | |
| Target pathways | NA | |
| IC50 | NA | |
| Potency | Among the tested alkaloids, C19-diterpenoid (e.g., lipojesaconitine, delcosine and delpheline derivatives) and C20-diterpenoid (e.g., kobusine and pseudokobusine derivatives) alkaloids exhibited significant cytotoxic activity and, thus, provide promising new leads for further development as antitumor agents. | |
| Cell line/ mice model | MCF-7, MDA-MB-231, A549, DU145,KB | |
| Additional information | NA | |
| PubChem ID | 441725 | |
| Additional PMIDs | 31234546 | |
| Additional sources of information | https://powo.science.kew.org/taxon/urn:lsid:ipni.org:names:707190-1 | |
| Safety | NA |