| Properties | Information | |
|---|---|---|
| PhytoCAT-ID | PhytoCAT-220 | |
| Phytochemical name or plant extracts | Chelidonine | |
| PMID | 25890994 | |
| Literature evidence | Chelidonine did not significantly inhibit the adhesion of the cells to type 1 collagen (COL-I), however it did affect cell spreading and reorganization of the actin cytoskeleton. | |
| IUPAC name | (1S,12S,13R)-24-methyl-5,7,18,20-tetraoxa-24-azahexacyclo[11.11.0.02,10.04,8.014,22.017,21]tetracosa-2,4(8),9,14(22),15,17(21)-hexaen-12-ol | |
| Phytochemicals’ class or type of plant extracts | Alkaloid | |
| Source of phytochemicals or plant Extracts | Chelidonium majus | |
| Geographical availability | Albania, Algeria, Altay, Amur, Austria, Azores, Baleares, Baltic States, Belarus, Belgium, Bulgaria, Buryatiya, Canary Is., Central European Rus, China North-Central, China South-Central, China Southeast, Chita, Corse, Czechoslovakia, Denmark, East European Russia, Finland, France, Germany, Greece, Hungary, Iran, Irkutsk, Italy, Kazakhstan, Khabarovsk, Kirgizstan, Korea, Krasnoyarsk, Krym, Madeira, Manchuria, Mongolia, Morocco, Netherlands, North Caucasus, North European Russi, Northwest European R, Norway, Poland, Portugal, Primorye, Qinghai, Romania, Sardegna, South European Russia, Spain, Sweden, Switzerland, Transcaucasus, Turkey, Turkey-in-Europe, Tuva, Ukraine, West Siberia, Yakutskiya, Yugoslavia | |
| Plant parts | NA | |
| Other cancers | Breast cancer | |
| Target gene or protein | AKT, ERK1/2 | |
| Gene or Protein evidence | These results suggest that chelidonine exhibits anti-migratory and anti-invasive effects in MDA-MB-231 cells, by suppressing COL-I-induced integrin signaling, through inhibiting the formation of the IPP complex and subsequent down-regulation of IPP downstream signaling molecules, such as Akt and ERK1/2. | |
| Target pathways | NA | |
| IC50 | 1.0±0.1 µM against MDA‑MB‑231 | |
| Potency | NA | |
| Cell line/ mice model | MDA-MB-231 | |
| Additional information | Chelidonine suppresses migration and invasion of MDA-MB-231 cells by inhibiting formation of the integrin-linked kinase/PINCH/α-parvin complex. | |
| PubChem ID | 197810 | |
| Additional PMIDs | 25265580 25890994 | |
| Additional sources of information | https://powo.science.kew.org/taxon/urn:lsid:ipni.org:names:303589-2 | |
| Safety | NA |