| Properties | Information | |
|---|---|---|
| PhytoCAT-ID | PhytoCAT-320 | |
| Phytochemical name or plant extracts | Terminamines B | |
| PMID | 22804108 | |
| Literature evidence | The aim of the present study was to identify potentially useful natural compounds for the development of novel therapeutic agents to inhibit metastasis. | |
| IUPAC name | [(1R,3S,4R,5R,8S,9S,10S,11R,13S,14S,16S,17S)-11-acetyloxy-17-[(1S)-1-(dimethylamino)ethyl]-4,16-dihydroxy-10,13-dimethyl-3-[(3S)-2-oxo-3-propan-2-ylazetidin-1-yl]-2,3,4,5,6,7,8,9,11,12,14,15,16,17-tetradecahydro-1H-cyclopenta[a]phenanthren-1-yl] acetate | |
| Phytochemicals’ class or type of plant extracts | Alkaloid | |
| Source of phytochemicals or plant Extracts | Pachysandra terminalis | |
| Geographical availability | China North-Central, China South-Central, China Southeast, Japan, Sakhalin | |
| Plant parts | Whole plant | |
| Other cancers | Breast cancer | |
| Target gene or protein | Epithelial growth factor | |
| Gene or Protein evidence | Compounds 1-5 and 8-14 inhibited the migration of MB-MDA-231 breast cancer cells induced by the chemokine epithelial growth factor. Compound 2 is Terminamines B | |
| Target pathways | NA | |
| IC50 | 0.20 μM against MDA-MB-231 | |
| Potency | NA | |
| Cell line/ mice model | MDA-MB-231 | |
| Additional information | NA | |
| PubChem ID | 70686928 | |
| Additional PMIDs | NA | |
| Additional sources of information | https://powo.science.kew.org/taxon/urn:lsid:ipni.org:names:353208-1 | |
| Safety | NA |