| Properties | Information | |
|---|---|---|
| PhytoCAT-ID | PhytoCAT-1746 | |
| Phytochemical name or plant extracts | Taspine | |
| PMID | 21605638 | |
| Literature evidence | Cell cycle and apoptosis analysis documented that taspine could change cell cycle and induce cell apoptosis. | |
| IUPAC name | 5-[2-(dimethylamino)ethyl]-7,14-dimethoxy-2,9-dioxatetracyclo[6.6.2.04,16.011,15]hexadeca-1(14),4(16),5,7,11(15),12-hexaene-3,10-dione | |
| Phytochemicals’ class or type of plant extracts | Alkaloid | |
| Source of phytochemicals or plant Extracts | Radix et Rhizomaeonticis | |
| Geographical availability | NA | |
| Plant parts | Rhizome | |
| Other cancers | Breast cancer | |
| Target gene or protein | ER, PR | |
| Gene or Protein evidence | There was a significant decrease observed in the expression of ER and PR both in tumor tissue and cells after treatment with taspine, RT-PCR also showed a reduction in the expression of mRNA for ER and PR in the group treated with taspine. | |
| Target pathways | NA | |
| IC50 | 1.69 μM against ZR-75-30 | |
| Potency | Taken together, these results suggested that taspine might serve as a promising candidate of ER antagonist in the treatment of oestrogen-independent breast cancer. | |
| Cell line/ mice model | ZR-75-30 human breast cancer xenografts in athymic mice | |
| Additional information | The results showed that treatment over 14 days resulted in a sustained and significant reduction in xenograft weight compared with untreated controls. Cell cycle and apoptosis analysis documented that taspine could change cell cycle and induce cell apoptosis. | |
| PubChem ID | 215159 | |
| Additional PMIDs | NA | |
| Additional sources of information | NA | |
| Safety | NA |