| PhytoCAT-ID | Phytochemical name or plant extracts | Source of phytochemicals or plant Extracts | Target gene or protein | Cell line/ mice model |
|---|---|---|---|---|
| PhytoCAT-44 | Cajanol | Cajanus cajan | Bcl-2, Bax, cyt-c, Caspase 3, caspase 9, PARP | MCF-7 |
| PhytoCAT-46 | Napabucasin | Handroanthus impetiginosus | STAT-3 | K562, MDA-MB-231 |
| PhytoCAT-47 | β-lapachone | Handroanthus impetiginosus | NA | K562, MDA-MB-231 |
| PhytoCAT-50 | Rhein | Rheum palmatum | PI3K, p-AKT, p-ERK, Hsp90α, NF-κB, COX-2, HER-2, HIF-1α, VEGF(165), EGF, TNF-α, IL-6, I-κB, Caspase 9, CHOP, , eIF2α, GRP78, FOXO, Akt | MCF-7, MDA-MB-435, MCF-7/HER2, MCF-7/VEC, MDA-MB-231, HepG2, 4T1 breast cancer xenografts in mice |
| PhytoCAT-80 | Lapachol | Plenckia populnea | NA | Breast cancer (4T1) tumor model, SKBR-3, MDA-MB-231, MCF-7 |
| PhytoCAT-89 | (-)-Cycloxanthochymol | Garcinia celebica | NA | HeLa, MCF-7, A549, B16 |
| PhytoCAT-90 | Isoxanthochymol | Garcinia celebica | NA | HeLa, MCF-7, A549, B16 |
| PhytoCAT-91 | Xanthochymol | Garcinia celebica | NA | HeLa, MCF-7, A549, B16 |
| PhytoCAT-132 | Cichorins F | Cichorium intybus | NA | MDA-MB-468, MDA-MB-231, SK-N-MC, PC-3 |
| PhytoCAT-182 | Eleutherine | Cipura paludosa | NA | U251, MCF-7, NCI-ADR, 786-0, NCI-H460, HT29, K562, HaCat |
| PhytoCAT-254 | Chimaphilin | Passiflora incarnata | Bcl-2, Bad, Caspase 9, Caspase 3, PARP | MCF-7 |
| PhytoCAT-335 | 9-O-demethyltrigonostemone | Strophioblachia fimbricalyx | NA | NCI-H187, KB, MCF-7 |
| PhytoCAT-337 | 2-methoxy-1, 4-naphthoquinone | Impatiens balsamina | GLUT1, AKT | MDA-MB-231 |
| PhytoCAT-374 | 2-Methoxystypandrone | Polygonum cuspidatum | STAT-3 | NA |
| PhytoCAT-505 | Deguelin | Mundulea sericea | NA | MDA-MB-231 |
| PhytoCAT-539 | Aloe-emodin | Aloe vera | Bcl-2, Bax, NF-κB, p38, ERK, miR-15a, miR-16-1, IL-1β, IL-6, VEGF, MMP2, MMP9 | MCF-10A, MCF-10AT, MCF-7, MDA-MB-231, 4T1 |
| PhytoCAT-541 | Aloin | Aloe vera | Topo II alpha, Cyclin B1 | MCF-7, SKBR-3 |
| PhytoCAT-544 | Kwanzoquinones A | Hemerocallis fulva | NA | NA |
| PhytoCAT-545 | Kwanzoquinones B | Hemerocallis fulva | NA | NA |
| PhytoCAT-546 | Kwanzoquinones C | Hemerocallis fulva | NA | NA |
| PhytoCAT-547 | Kwanzoquinones E | Hemerocallis fulva | NA | NA |
| PhytoCAT-695 | Plumbagin | Plumbago zeylanica | NQO1, NF-kB, MMP9, Akt, IKKalpha | MCF-7, MDA-MB-231, HeLa, A549 |
| PhytoCAT-778 | Nordamnacanthal | Morinda citrifolia | NA | MDA-MB-231, MCF-7 and 4T1/ Balb/C mice |
| PhytoCAT-784 | Alizarin | Rubia tinctorum | NA | MDA-MB-231 |
| PhytoCAT-800 | Emodic-acid | Asphodelus microcarpus | JNK, p38, ERK, IL-1β, IL-6, VEGF, MMP2, MMP9 | 4T1 |
| PhytoCAT-875 | Mansonone-G | Mansonia gagei | NA | MCF-7, HepG2, HCT-116, HeLa |
| PhytoCAT-876 | Mansonone-N | Mansonia gagei | NA | MCF-7, HepG2, HCT-116, HeLa |
| PhytoCAT-985 | 8,8′-Oxo-biplumbagin | Diospyros shimbaensis | NA | MDA-MB-231 |
| PhytoCAT-988 | 3,3′-Biplumbagin | Diospyros shimbaensis | NA | MDA-MB-231 |
| PhytoCAT-1098 | Embelin | Embelia ribes | SOD1, ERK1, ERK2, Bax, Bcl-2, XIAP | MCF-7, 4T1 |
| PhytoCAT-1145 | Thymoquinone (TQ) | Nigella sativa | HSPA6, CXCR4, p53, DNMT1,3A,3B, G9A, HDAC1,4,9, KDM1B, KMT2A,B,C,D,E, DLC1, PPARG, ST7, FOXO6, TET2, CYP1B1, SALL4, DDIT3, RASL11B, RASD1, GNG3, BAD, BIK | MCF-7, MBD-MB 231 |
| PhytoCAT-1172 | Emodin | Rheum palmatum | IRF4, STAT6, Runx2, Bcl-2, Bax, Cytochrome c, MMP9, activator -1, NF-κB, miR-34a, IRF4, EMT | MCF-7, 4T1, ZR-75-1, MDA-MB-453, MDA-MB-231, mice bearing EO771 or 4T1 |
| PhytoCAT-1201 | Celastrol | Tripterygium wilfordii Hook F | CXCR4, NF- kB, MMP9, DCLK1, ALDH1, CD133 | MDA-MB-231, MCF-7 |
| PhytoCAT-1232 | Rhinacanthin A | Rhinacanthus nasutus | NA | MCF-7 |
| PhytoCAT-1244 | Antroquinonol (AQ) | Antrodia camphorata | IL-10, PTGS2, IL-6 | MCF-7, MDA-MB-231, Hep3B, HepG2, DU-145, LNCaP |
| PhytoCAT-1280 | Phaitanthrin A | Cephalantheropsis gracilis | NA | MCF-7, NCI-H460, and SF-268 |
| PhytoCAT-1313 | 1-hydroxy-5-pentyl-Quinone | Juglans mandshurica | NA | MDA-MB-231, HepG2, SNU638 |
| PhytoCAT-1314 | 4-(5-hydroxy-1,4-dioxo-1,4-dihydro-naphthalen-2-ylamino)-butyric acid methyl ester | Juglans mandshurica | NA | MDA-MB-231, HepG2, SNU638 |
| PhytoCAT-1315 | 5-hydroxy-2-(2-hydroxy-ethylamino)-(1,4) naphthoquinone | Juglans mandshurica | NA | MDA-MB-231, HepG2, SNU638 |
| PhytoCAT-1316 | Juglone | Juglans mandshurica | NA | MDA-MB-231, HepG2, SNU638 |
| PhytoCAT-1390 | Dehydrooopodin | Ferula oopoda | NA | MCF-7 and K562 |
| PhytoCAT-1451 | Obolactone | Cryptocarya yunnanensis | NA | A549, HCT-116, MDA-MB-231, PC-3, HeLa |
| PhytoCAT-1454 | 7',8'-Dihydroobolactone | Cryptocarya yunnanensis | NA | HCT-116, MDA-MB-231, PC-3 |
| PhytoCAT-1495 | Nemorosone | Clusia rosea | ESR2, GRB7, MAPK3, MLH1, MYC, Notch1, PRDM2, THBS1, Tp53, VEGFA, APC, CCND1, CCNE1, ESR1, IGFBP3, KRT19, MKI6, MUC1, PG | MCF-7 BUS, MCF-7, MDA-MB-231 |
| PhytoCAT-1560 | Salvicine | Chinese herb | topo II, mdr-1, Bcl-2, p38 MAPK, ERK, DNA-dependent kinase (DNA-PK(CS)) | MCF-7, MDA-MB-435, MDR K562/A02, K562/A02, KB/VCR and MCF-7/ADR, K562, KB |
| PhytoCAT-1687 | 3-(5-oxohexyl)plumbagin | Diospyros undulata | NA | NCI-H187, MCF-7, KB |
| PhytoCAT-1740 | Malabaricone C (mal C) | NA | NA | MCF-7 |
| PhytoCAT-1747 | Alterporriol K | NA | NA | MDA-MB-435, MCF-7 |
| PhytoCAT-1748 | Alterporriol L | NA | NA | MDA-MB-435 and MCF-7 |
| PhytoCAT-1768 | Geranyl (3-GAP) | NA | p53, cyt-c, Bax, Caspase 3, Caspase 7, Caspase 9 | MCF-7, HT1080 |
| PhytoCAT-1868 | Shikonin | Lithospermum erythrorhizon | DUSP1, DUSP2, ERα, GPER, EGFR, p-ERK, RIP1K, RIP3K, E-cadherin, N-cadherin, vimentin, Snail | MDA-MB-468, MDA-MB-231, MCF-7, SKBR-3 |
| PhytoCAT-1973 | Parietin | NA | NA | A2780, HeLa, MCF-7, SKBR-3, HT-29, HCT-116 p53(+/+), HCT-116 p53(-/-), HL-60 and Jurkat |
| PhytoCAT-1981 | 1,3,6-Trihydroxy-7-methyl-9,10-anthracenedione | Lindera | Fatty acid synthase | MDA-MB-231 |
| PhytoCAT-1992 | 2-acetylfuro-1,4-naphthoquinone | Newbouldia laevis | NA | CCRF-CEM, CEM/ADR5000, PF-382, HL-60, MiaPaCa-2, Capan-1, MCF-7, SW-680, 786-0, U87MG, A549, Colo-38, HeLa, Caski |
| PhytoCAT-2009 | (2'R)-6-(2'-acetoxytridecyl)-2-methoxy-1,4-dihydroxybenzene | Ardisia virens | NA | MCF-7, NCI-H460, SF-268 |
| PhytoCAT-2010 | 1-acetoxy-2-methoxy-6-pentadecyl-4-hydroxybenzene | Ardisia virens | NA | MCF-7, NCI-H460, SF-268 |
| PhytoCAT-2011 | 1-acetoxy-2-methoxy-6-tridecyl-4-hydroxybenzene | Ardisia virens | NA | MCF-7, NCI-H460, SF-268 |
| PhytoCAT-2012 | (2'R)-1-acetoxy-6-(2'-acetoxy-tridecyl)-2-methoxy-4-hydroxybenzene | Ardisia virens | NA | MCF-7, NCI-H460, SF-268 |
| PhytoCAT-2058 | 2-acetyl-7-methoxynaphtho[2,3-b]furan-4,9-quinone (AMNQ) | Millettia versicolor | NA | MDA-MB-231/BCRP, HepG2, CCRF-CEM |
| PhytoCAT-2075 | Onosma hookeri Clarke. var. longiforum Duthie (OHC-LD) extract | Onosma hookeri | NA | MCF-7 |