| Properties | Information | |
|---|---|---|
| PhytoCAT-ID | PhytoCAT-800 | |
| Phytochemical name or plant extracts | Emodic-acid | |
| PMID | 33988779 | |
| Literature evidence | The pharmacological actions of Quinone in cancer cells are known to induce apoptosis or autophagy, and revert multidrug resistance. | |
| IUPAC name | 4,5,7-trihydroxy-9,10-dioxoanthracene-2-carboxylic acid | |
| Phytochemicals’ class or type of plant extracts | Quinone | |
| Source of phytochemicals or plant Extracts | Asphodelus microcarpus | |
| Geographical availability | Albania, Algeria, Azores, Baleares, Canary Is., Cape Verde, Corse, Cyprus, East Aegean Is., France, Greece, Italy, Kriti, Lebanon-Syria, Libya, Mauritius, Morocco, Oman, Palestine, Portugal, Sardegna, Saudi Arabia, Sicilia, Sinai, Spain, Transcaucasus, Tunisia, Turkey, Turkey-in-Europe, Yugoslavia | |
| Plant parts | Leaves | |
| Other cancers | Breast cancer | |
| Target gene or protein | JNK, p38, ERK, IL-1β, IL-6, VEGF, MMP2, MMP9 | |
| Gene or Protein evidence | Although aloe-emodin inhibited p38 and ERK phosphorylation, emodic-acid more markedly inhibited JNK, in addition to p38 and ERK phosphorylation. Both aloe-emodin and emodic-acid inhibited the secretion of the pro-tumorigenic cytokines IL-1β and IL-6, and VEGF and MMP expression | |
| Target pathways | NF-κB and MAP kinase pathways | |
| IC50 | NA | |
| Potency | Among them, aloe-emodin and emodic-acid strongly inhibited the proliferation, cells-intrinsic NF-κB activity and metastatic ability of breast cancer. | |
| Cell line/ mice model | 4T1 | |
| Additional information | Thus, our study demonstrated the effects of aloe-emodin and emodin-acid in controlling the migratory and invasive ability of 4T1 breast cancer cells, in addition to inhibiting NF-κB activity and the expression of its downstream target molecules. | |
| PubChem ID | 361510 | |
| Additional PMIDs | NA | |
| Additional sources of information | https://powo.science.kew.org/taxon/urn:lsid:ipni.org:names:77169075-1 | |
| Safety | NA |