| Properties | Information | |
|---|---|---|
| PhytoCAT-ID | PhytoCAT-80 | |
| Phytochemical name or plant extracts | Lapachol | |
| PMID | 33254016 | |
| Literature evidence | Lapachol (LAP) is a natural compound with various biological properties, including anticancer activity. | |
| IUPAC name | 4-hydroxy-3-(3-methylbut-2-enyl)naphthalene-1,2-dione | |
| Phytochemicals’ class or type of plant extracts | Quinone | |
| Source of phytochemicals or plant Extracts | Plenckia populnea | |
| Geographical availability | Bolivia, Brazil North, Brazil Northeast, Brazil South, Brazil Southeast, Brazil West-Central, Paraguay | |
| Plant parts | NA | |
| Other cancers | Breast cancer | |
| Target gene or protein | NA | |
| Gene or Protein evidence | NA | |
| Target pathways | NA | |
| IC50 | 72.3 μmol/L against SKBR-3 8.29 ± 3.07 μM against 4T1 6.60 ± 3.1 μM against MDA-MB-231 | |
| Potency | The present study is the first to demonstrate that probiotics are capable of converting lapachol into the most effective cytotoxic compound against a breast cancer cell line. | |
| Cell line/ mice model | Breast cancer (4T1) tumor model, SKBR-3, MDA-MB-231, MCF-7 | |
| Additional information | NA | |
| PubChem ID | 3884 | |
| Additional PMIDs | 9567326 30679039 24635204 | |
| Additional sources of information | https://powo.science.kew.org/taxon/urn:lsid:ipni.org:names:162368-1 | |
| Safety | NA |