| Properties | Information | |
|---|---|---|
| PhytoCAT-ID | PhytoCAT-132 | |
| Phytochemical name or plant extracts | Cichorins F | |
| PMID | 32932909 | |
| Literature evidence | Moreover compounds 1-3 did not show any promising anthelmintic effects. | |
| IUPAC name | NA | |
| Phytochemicals’ class or type of plant extracts | Anthraquinone | |
| Source of phytochemicals or plant Extracts | Cichorium intybus | |
| Geographical availability | Afghanistan, Albania, Algeria, Austria, Azores, Baleares, Baltic States, Belarus, Belgium, Bulgaria, Cape Verde, Central European Rus, Corse, Cyprus, Czechoslovakia, Denmark, East Aegean Is., East European Russia, Egypt, Finland, France, Germany, Greece, Hungary, Iran, Iraq, Italy, Kazakhstan, Kirgizstan, Kriti, Krym, Lebanon-Syria, Morocco, Netherlands, North Caucasus, North European Russi, Northwest European R, Norway, Pakistan, Palestine, Poland, Portugal, Romania, Sardegna, Sicilia, Sinai, South European Russi, Spain, Sweden, Switzerland, Tadzhikistan, Transcaucasus, Tunisia, Turkey, Turkey-in-Europe, Turkmenistan, Ukraine, Uzbekistan, West Himalaya, Yugoslavia | |
| Plant parts | Whole plant | |
| Other cancers | Breast cancer, Ewing's sarcoma, Prostate cancer | |
| Target gene or protein | NA | |
| Gene or Protein evidence | NA | |
| Target pathways | NA | |
| IC50 | MTT assay IC50 = 41.0 µM against MDA-MB-468 CV assay IC50 = 47.7 µM µM against MDA-MB-468 MTT assay IC50 = 45.6 µM against MDA-MB-231 CV assay IC50 = 49.1 µM µM against MDA-MB-231 | |
| Potency | Highest anti-proliferative and cytotoxic activity, respectively, was found for Cichorins F. | |
| Cell line/ mice model | MDA-MB-468, MDA-MB-231, SK-N-MC, PC-3 | |
| Additional information | Phytochemical investigations of C. intybus provided two new naphthalane derivatives viz., cichorins D (1) and E (2) along with one new Quinone, cichorin F (3). | |
| PubChem ID | NA | |
| Additional PMIDs | NA | |
| Additional sources of information | https://powo.science.kew.org/taxon/urn:lsid:ipni.org:names:194533-1 | |
| Safety | NA |