| Properties | Information | |
|---|---|---|
| PhytoCAT-ID | PhytoCAT-539 | |
| Phytochemical name or plant extracts | Aloe-emodin | |
| PMID | 33988779 | |
| Literature evidence | The pharmacological actions of anthraquinones in cancer cells are known to induce apoptosis or autophagy, and revert multidrug resistance. | |
| IUPAC name | 1,8-dihydroxy-3-(hydroxymethyl)anthracene-9,10-dione | |
| Phytochemicals’ class or type of plant extracts | Quinone | |
| Source of phytochemicals or plant Extracts | Aloe vera | |
| Geographical availability | Oman | |
| Plant parts | NA | |
| Other cancers | Breast cancer | |
| Target gene or protein | Bcl-2, Bax, NF-κB, p38, ERK, miR-15a, miR-16-1, IL-1β, IL-6, VEGF, MMP2, MMP9 | |
| Gene or Protein evidence | Mechanistically, AE dose-dependently decreased the protein expression of Bcl-2 and Bcl-xl, while it increased Bax protein expression in MCF-10AT and MCF-7 cells. Thus, our study demonstrated the effects of aloe-emodin and emodin-acid in controlling the migratory and invasive ability of 4T1 breast cancer cells, in addition to inhibiting NF-κB activity and the expression of its downstream target molecules. lthough aloe-emodin inhibited p38 and ERK phosphorylation. Along with the mRNA expression, the enzymatic activities of MMP-2 and 9 in 4T1 cells were inhibited by both aloe-emodin and emodicacid in a dose-dependent manner Both aloe-emodin and emodic-acid inhibited the secretion of the pro-tumorigenic cytokines IL-1β and IL-6, and VEGF and MMP expression, and subsequently inhibited the invasive and migratory potential of 4T1 cells. In all candidate miRNAs that bind to 3'-UTR of Bcl-2, miR-15a and miR-16-1 were dose-dependently downregulated by AE. | |
| Target pathways | Caspase-8 pathway | |
| IC50 | 35.75 μM for 72 h against MCF-10AT 43.49 μM 72 h against MCF-10AT | |
| Potency | Moreover, inhibition of miR-15a/16-1 could eliminate the inhibition of MCF-10AT and MCF-7 cells growth by AE and could reverse the downregulation of AE-induced Bcl-2 protein level. | |
| Cell line/ mice model | MCF-10A, MCF-10AT, MCF-7, MDA-MB-231, 4T1 | |
| Additional information | Our research provides an important basis that AE induces BT cell apoptosis through upregulation of miR-15a/miR-16-1 that suppresses BCL2. | |
| PubChem ID | 10207 | |
| Additional PMIDs | 34124677 24577925 11459643 18563353 30600703 33988779 32190086 27703348 29783719 | |
| Additional sources of information | https://powo.science.kew.org/taxon/urn:lsid:ipni.org:names:530017-1 | |
| Safety | NA |