| Properties | Information | |
|---|---|---|
| PhytoCAT-ID | PhytoCAT-90 | |
| Phytochemical name or plant extracts | Isoxanthochymol | |
| PMID | 34829884 | |
| Literature evidence | The antioxidant and cytotoxicity evaluation showed that all benzophenones exhibited antioxidant activity compared to gallic acid and quercetin as positive controls and also exhibited strong activity against HeLa, MCF-7, A549, and B16 cell lines compared to cisplatin as the positive control. | |
| IUPAC name | (1R,3R,9S,11S)-7-(3,4-dihydroxybenzoyl)-4,4,10,10-tetramethyl-3,9,11-tris(3-methylbut-2-enyl)-5-oxatricyclo[7.3.1.01,6]tridec-6-ene-8,13-dione | |
| Phytochemicals’ class or type of plant extracts | Polyprenylated benzophenones | |
| Source of phytochemicals or plant Extracts | Garcinia celebica | |
| Geographical availability | Andaman Is., Assam, Bangladesh, Bismarck Archipelago, Borneo, Cambodia, Jawa, Laos, Lesser Sunda Is., Malaya, Maluku, Myanmar, New Guinea, Nicobar Is., Philippines, Solomon Is., Sulawesi, Sumatera, Thailand, Vietnam | |
| Plant parts | Root | |
| Other cancers | Breast cancer, Cervical cancer, Lung cancer | |
| Target gene or protein | NA | |
| Gene or Protein evidence | NA | |
| Target pathways | NA | |
| IC50 | 10.73 ± 0.14 μM against MCF-7 | |
| Potency | Additionally, the ADMET prediction indicated compounds 1–3 were potential oral drug candidates. | |
| Cell line/ mice model | HeLa, MCF-7, A549, B16 | |
| Additional information | The antiplasmodial evaluation showed that isoxanthochymol exhibited activity against the chloroquine-sensitive P. falciparum strain 3D7. | |
| PubChem ID | 10461245 | |
| Additional PMIDs | NA | |
| Additional sources of information | https://powo.science.kew.org/taxon/urn:lsid:ipni.org:names:169645-1 | |
| Safety | NA |