| Properties | Information | |
|---|---|---|
| PhytoCAT-ID | PhytoCAT-44 | |
| Phytochemical name or plant extracts | Cajanol | |
| PMID | 20638373 | |
| Literature evidence | Cajanol, a novel anticancer agent from Pigeonpea [Cajanus cajan (L.) Millsp.] roots, induces apoptosis in human breast cancer cells through a ROS-mediated mitochondrial pathway. | |
| IUPAC name | 5-hydroxy-3-(4-hydroxy-2-methoxyphenyl)-7-methoxy-2,3-dihydrochromen-4-one | |
| Phytochemicals’ class or type of plant extracts | Isoflavanone | |
| Source of phytochemicals or plant Extracts | Cajanus cajan | |
| Geographical availability | Assam, India, West Himalaya | |
| Plant parts | Root | |
| Other cancers | Breast cancer | |
| Target gene or protein | Bcl-2, Bax, cyt-c, Caspase 3, caspase 9, PARP | |
| Gene or Protein evidence | Western blot analysis showed that cajanol inhibited Bcl-2 expression and induced Bax expression to desintegrate the outer mitochondrial membrane and causing cytochrome c release. Mitochondrial cytochrome c release was associated with the activation of caspase-9 and caspase-3 cascade, and active-caspase-3 was involved in PARP cleavage. | |
| Target pathways | NA | |
| IC50 | At 72h, 48h, 24h respectively: 54.05 μM against MCF-7 58.32 μM against MCF-7 83.42 μM against MCF-7 | |
| Potency | Cajanol inhibited the growth of MCF-7 cells in a time and dose-dependent manner. | |
| Cell line/ mice model | MCF-7 | |
| Additional information | Mitochondrial cytochrome c release was associated with the activation of caspase-9 and caspase-3 cascade, and active-caspase-3 was involved in PARP cleavage. All of these signal transduction pathways are involved in initiating apoptosis. | |
| PubChem ID | 442670 | |
| Additional PMIDs | NA | |
| Additional sources of information | https://powo.science.kew.org/taxon/urn:lsid:ipni.org:names:1152177-2 | |
| Safety | NA |