| Properties | Information | |
|---|---|---|
| PhytoCAT-ID | PhytoCAT-876 | |
| Phytochemical name or plant extracts | Mansonone-N | |
| PMID | 29701706 | |
| Literature evidence | Mansorin-B and mansonone-G were found to inhibit the P-gp attached ATPase subunit. | |
| IUPAC name | (1R,4R)-1,5-dihydroxy-6-methoxy-4,7-dimethyl-1-propan-2-yl-3,4-dihydronaphthalen-2-one | |
| Phytochemicals’ class or type of plant extracts | Quinone | |
| Source of phytochemicals or plant Extracts | Mansonia gagei | |
| Geographical availability | Laos, Myanmar, Thailand | |
| Plant parts | Heartwood | |
| Other cancers | Breast cancer, Cervical cancer, Colorectal cancer, Liver cancer | |
| Target gene or protein | NA | |
| Gene or Protein evidence | NA | |
| Target pathways | NA | |
| IC50 | >100 µM against MCF-7 | |
| Potency | Mansonone-N and mansorin I showed weak cytotoxicity with IC50 higher than 100 μM. | |
| Cell line/ mice model | MCF-7, HepG2, HCT-116, HeLa | |
| Additional information | Only mansonone-N did not show any cytotoxicity against HeLa cells with IC50 higher that 100 μM and mansorin-III suffered from resistant fraction higher than 30%. | |
| PubChem ID | 637435 | |
| Additional PMIDs | NA | |
| Additional sources of information | https://powo.science.kew.org/taxon/urn:lsid:ipni.org:names:824303-1 | |
| Safety | NA |