| Properties | Information | |
|---|---|---|
| PhytoCAT-ID | PhytoCAT-695 | |
| Phytochemical name or plant extracts | Plumbagin | |
| PMID | 31276663 | |
| Literature evidence | Plumbagin induced ER stress mainly by inhibiting the chymotrypsin-like activity of 26S proteasome as also evident from the accumulation of polyubiquitinated proteins. | |
| IUPAC name | 5-hydroxy-2-methylnaphthalene-1,4-dione | |
| Phytochemicals’ class or type of plant extracts | Quinone | |
| Source of phytochemicals or plant Extracts | Plumbago zeylanica | |
| Geographical availability | Andaman Is., Angola, Argentina Northwest, Arizona, Aruba, Assam, Bahamas, Bangladesh, Benin, Bolivia, Botswana, Brazil North, Brazil Northeast, Brazil South, Brazil Southeast, Brazil West-Central, Burkina, Burundi, Cameroon, Cape Provinces, Central African Repu, Chad, China South-Central, China Southeast, Christmas I., Colombia, Comoros, Congo, Costa Rica, Cuba, Djibouti, Dominican Republic, East Himalaya, Ecuador, El Salvador, Eritrea, Ethiopia, Florida, Free State, French Guiana, Galápagos, Gambia, Ghana, Guatemala, Guinea, Guinea-Bissau, Gulf of Guinea Is., Hainan, Haiti, Hawaii, Honduras, India, Ivory Coast, Jamaica, Jawa, Kenya, KwaZulu-Natal, Laos, Leeward Is., Lesser Sunda Is., Liberia, Madagascar, Malawi, Malaya, Mali, Marianas, Marquesas, Mexico Central, Mexico Southwest, Mozambique, Namibia, Nepal, Netherlands Antilles, New Guinea, New South Wales, Nicaragua, Niger, Nigeria, Norfolk Is., Northern Provinces, Northern Territory, Oman, Pakistan, Paraguay, Peru, Philippines, Puerto Rico, Queensland, Rwanda, Saudi Arabia, Senegal, Sierra Leone, Society Is., Somalia, Southwest Caribbean, Sri Lanka, Sudan, Sulawesi, Sumatera, Suriname, Swaziland, Taiwan, Tanzania, Texas, Thailand, Togo, Trinidad-Tobago, Tubuai Is., Turks-Caicos Is., Uganda, Venezuela, Venezuelan Antilles, Vietnam, West Himalaya, Western Australia, Windward Is., Yemen, Zambia, Zaïre, Zimbabwe | |
| Plant parts | Stem and Root | |
| Other cancers | Breast cancer, Cervical cancer, Lung cancer | |
| Target gene or protein | NQO1, NF-kB, MMP9, Akt, IKKalpha | |
| Gene or Protein evidence | NADPH: Quinone oxidoreductase 1 (NQO1) mediated anti-cancer effects of plumbagin in endocrine resistant MCF7 breast cancer cells. In conclusion, plumbagin inhibits the invasion of HER2-overexpressing breast cancer cells through the inhibition of IKKalpha-mediated NF-kB activation and downregulation of NF-κB-regulated MMP-9 expression. We also found that plumbagin inhibited survival signaling through the phosphatidylinositol 3-kinase/AKT signaling pathway by blocking the activation of AKT and downstream targets, including the mammalian target of rapamycin, forkhead transcription factors, and glycogen synthase kinase 3beta. | |
| Target pathways | Phosphatidylinositol 3-kinase/AKT signaling pathway | |
| IC50 | 1.28 μM against MCF-7 130.8 μM against MDA-MB-231 | |
| Potency | A plant metabolite, plumbagin, has potent anticancer activity via reactive oxygen species (ROS) generation. EC50 = >25 microM | |
| Cell line/ mice model | MCF-7, MDA-MB-231, HeLa, A549 | |
| Additional information | These results imply that plumbagin inhibits ERK activation in breast cancer cells, which plays a role in the sensitization of cells to paclitaxel-induced cell death. | |
| PubChem ID | 10205 | |
| Additional PMIDs | 28933383 27727280 31276663 33344645 23028742 15261389 17172425 30810041 | |
| Additional sources of information | https://powo.science.kew.org/taxon/urn:lsid:ipni.org:names:687109-1 | |
| Safety | Acute toxic in pubchem database |