| Properties | Information | |
|---|---|---|
| PhytoCAT-ID | PhytoCAT-1495 | |
| Phytochemical name or plant extracts | Nemorosone | |
| PMID | 25636884 | |
| Literature evidence | While estrogen receptor antagonists have been widely used in breast cancer treatment, patients have increasingly shown resistance to these agents and the identification of novel targeted therapies is therefore required. | |
| IUPAC name | (1R,5R,7S)-1-benzoyl-4-hydroxy-8,8-dimethyl-3,5,7-tris(3-methylbut-2-enyl)bicyclo[3.3.1]non-3-ene-2,9-dione | |
| Phytochemicals’ class or type of plant extracts | Polycyclic polyisoprenylated benzophenones | |
| Source of phytochemicals or plant Extracts | Clusia rosea | |
| Geographical availability | Aruba, Bahamas, Belize, Cayman Is., Central American Pac, Colombia, Costa Rica, Cuba, Dominican Republic, Ecuador, El Salvador, Florida, French Guiana, Guatemala, Guyana, Haiti, Honduras, Jamaica, Leeward Is., Mexico Gulf, Mexico Southeast, Mexico Southwest, Netherlands Antilles, Nicaragua, Panamá, Puerto Rico, Suriname, Trinidad-Tobago, Turks-Caicos Is., Venezuela, Venezuelan Antilles, Windward Is. | |
| Plant parts | Floral resin | |
| Other cancers | Breast cancer | |
| Target gene or protein | ESR2, GRB7, MAPK3, MLH1, MYC, Notch1, PRDM2, THBS1, Tp53, VEGFA, APC, CCND1, CCNE1, ESR1, IGFBP3, KRT19, MKI6, MUC1, PG | |
| Gene or Protein evidence | In comparison to breast cancer cells without treatment, nemorosone induced discrete cell cycle arrest in the G1 phase and significant depletion in the G2 phase. Moreover, the compound altered the expression of 19 genes related to different pathways, especially the cell cycle, apoptosis and hormone receptors. | |
| Target pathways | The expression of pERK1/2 and pAkt, considered to be hallmarks of the nongenomic estrogen signalling pathway, were reduced in MCF-7 cells treated with nemorosone. | |
| IC50 | NA | |
| Potency | These findings suggest that nemorosone may have therapeutic application in the treatment of breast cancer because of its activity on ER?. | |
| Cell line/ mice model | MCF-7 BUS, MCF-7, MDA-MB-231 | |
| Additional information | In comparison to breast cancer cells without treatment, nemorosone induced discrete cell cycle arrest in the G1 phase and significant depletion in the G2 phase. | |
| PubChem ID | 637105 | |
| Additional PMIDs | 21186377 | |
| Additional sources of information | https://powo.science.kew.org/taxon/urn:lsid:ipni.org:names:61583-2 | |
| Safety | NA |