| Properties | Information | |
|---|---|---|
| PhytoCAT-ID | PhytoCAT-374 | |
| Phytochemical name or plant extracts | 2-Methoxystypandrone | |
| PMID | 22855270 | |
| Literature evidence | Thus, the identification of small molecules that modulate STAT3 activity could be of great therapeutic importance. | |
| IUPAC name | 6-acetyl-5-hydroxy-2-methoxy-7-methylnaphthalene-1,4-dione | |
| Phytochemicals’ class or type of plant extracts | Quinone | |
| Source of phytochemicals or plant Extracts | Polygonum cuspidatum | |
| Geographical availability | Amur, China North-Central, China South-Central, China Southeast, Hainan, Japan, Khabarovsk, Korea, Kuril Is., Manchuria, Nansei-shoto, Primorye, Sakhalin, Taiwan | |
| Plant parts | Root | |
| Other cancers | Breast cancer | |
| Target gene or protein | STAT-3 | |
| Gene or Protein evidence | Compound 1 demonstrated a potent inhibitory effect on STAT3 activation and significantly inhibited cell proliferation of human breast cancer cells, especially those with constitutively activated STAT3 (IC₅₀ = 2.7-3.1 µM). | |
| Target pathways | STAT3 signaling pathway | |
| IC50 | 7.86 ± 0.05 µM against MDA‑MB‑453 3.08 ± 0.26 µM against MDA‑MB‑468 2.77 ± 0.26 µM against MDA‑MB‑231 | |
| Potency | NA | |
| Cell line/ mice model | NA | |
| Additional information | NA | |
| PubChem ID | 158739 | |
| Additional PMIDs | NA | |
| Additional sources of information | https://powo.science.kew.org/taxon/urn:lsid:ipni.org:names:435655-1 | |
| Safety | NA |