| Properties | Information | |
|---|---|---|
| PhytoCAT-ID | PhytoCAT-875 | |
| Phytochemical name or plant extracts | Mansonone-G | |
| PMID | 29701706 | |
| Literature evidence | Mansorin-B and mansonone-G were found to inhibit the P-gp attached ATPase subunit. | |
| IUPAC name | 6-hydroxy-3,8-dimethyl-5-propan-2-ylnaphthalene-1,2-dione | |
| Phytochemicals’ class or type of plant extracts | Quinone | |
| Source of phytochemicals or plant Extracts | Mansonia gagei | |
| Geographical availability | Laos, Myanmar, Thailand | |
| Plant parts | Heartwood | |
| Other cancers | Breast cancer, Cervical cancer, Colorectal cancer, Liver cancer | |
| Target gene or protein | NA | |
| Gene or Protein evidence | NA | |
| Target pathways | NA | |
| IC50 | 23.0 µM against MCF-7 | |
| Potency | Only mansorin-B and mansonone-G showed pure ATPase inhibitory effects with 155.6% and 137.0% more remaining ATP concentration, respectively | |
| Cell line/ mice model | MCF-7, HepG2, HCT-116, HeLa | |
| Additional information | In HepG2 liver cancer cells, mansorin-B, mansorin I, mansonone-G and mansorin II showed relatively potent cytotoxic profile at an R-value less than 20% and IC50s ranging from 21.9 μM to 49.4 μM. | |
| PubChem ID | 608583 | |
| Additional PMIDs | NA | |
| Additional sources of information | https://powo.science.kew.org/taxon/urn:lsid:ipni.org:names:824303-1 | |
| Safety | NA |