| Properties | Information | |
|---|---|---|
| PhytoCAT-ID | PhytoCAT-778 | |
| Phytochemical name or plant extracts | Nordamnacanthal | |
| PMID | 29374471 | |
| Literature evidence | Moreover, based on the cell cycle and Annexin V results, nordamnacanthal managed to induce cell death in both MDA-MB231 and MCF-7 cells. | |
| IUPAC name | 1,3-dihydroxy-9,10-dioxoanthracene-2-carbaldehyde | |
| Phytochemicals’ class or type of plant extracts | Anthraquinone | |
| Source of phytochemicals or plant Extracts | Morinda citrifolia | |
| Geographical availability | Andaman Is., Assam, Bangladesh, Bismarck Archipelago, Borneo, Cambodia, China Southeast, Christmas I., Cocos (Keeling) Is., Hainan, India, Jawa, Kazan-retto, Laccadive Is., Lesser Sunda Is., Malaya, Maldives, Maluku, Myanmar, Nansei-shoto, New Guinea, Nicobar Is., Northern Territory, Ogasawara-shoto, Philippines, Queensland, Santa Cruz Is., Solomon Is., South China Sea, Sri Lanka, Sulawesi, Sumatera, Taiwan, Thailand, Vietnam, Western Australia | |
| Plant parts | Fruits, root | |
| Other cancers | Breast cancer | |
| Target gene or protein | NA | |
| Gene or Protein evidence | NA | |
| Target pathways | NA | |
| IC50 | 8.0 ± 1.2 μg/mL against MCF-7, 10.0 ± 0.8 μg/mL against MDA-MB231, 11.0 ± 1.0 μg/mL against 4T1 | |
| Potency | Nordamnacanthal managed to inhibit the growth and induce cell death in MDA-MB231 and MCF-7 cell lines in vitro and cease the tumor progression of 4T1 cells in vivo. | |
| Cell line/ mice model | MDA-MB-231, MCF-7 and 4T1/ Balb/C mice | |
| Additional information | Treatment with nordamnacanthal was also able to increase tumor immunity as evidenced by the immunophenotyping of the spleen and YAC-1 cytotoxicity assays. | |
| PubChem ID | 160712 | |
| Additional PMIDs | 21214480 | |
| Additional sources of information | https://powo.science.kew.org/taxon/urn:lsid:ipni.org:names:756359-1 | |
| Safety | NA |