| Properties | Information | |
|---|---|---|
| PhytoCAT-ID | PhytoCAT-254 | |
| Phytochemical name or plant extracts | Chimaphilin | |
| PMID | 24793375 | |
| Literature evidence | Furthermore, free radical scavengers N-acetyl-L-cysteine (NAC) pretreatment test testified that chimaphilin could increase the generation of ROS, then induce cell apoptosis. | |
| IUPAC name | 2,7-dimethylnaphthalene-1,4-dione | |
| Phytochemicals’ class or type of plant extracts | Quinone | |
| Source of phytochemicals or plant Extracts | Passiflora incarnata | |
| Geographical availability | Argentina Northeast, Brazil Northeast, Brazil South, Brazil Southeast, Brazil West-Central, Paraguay | |
| Plant parts | NA | |
| Other cancers | Breast cancer | |
| Target gene or protein | Bcl-2, Bad, Caspase 9, Caspase 3, PARP | |
| Gene or Protein evidence | chimaphilin suppressed Bcl-2 level and enhanced Bad level, then activated caspase-9 and caspase-3, and further activated the poly ADP-ribose polymerase (PARP), finally induced cell apoptosis involving the mitochondrial pathway. | |
| Target pathways | ROS-mediated mitochondrial pathway | |
| IC50 | 43.30 μM against MCF-7 | |
| Potency | Chimaphilin could inhibit the viability of MCF-7 cells in a concentration-dependent manner, and the IC50 value was 43.30μM for 24h. Chimaphilin markedly induced apoptosis through the investigation of characteristic apoptotic morphological changes, nuclear DNA fragmentation | |
| Cell line/ mice model | MCF-7 | |
| Additional information | Flow cytometry assay revealed that chimaphilin triggered a significant generation of ROS and disruption of mitochondrial membrane potential. | |
| PubChem ID | 101211 | |
| Additional PMIDs | NA | |
| Additional sources of information | https://powo.science.kew.org/taxon/urn:lsid:ipni.org:names:321964-2 | |
| Safety | NA |