| Properties | Information | |
|---|---|---|
| PhytoCAT-ID | PhytoCAT-505 | |
| Phytochemical name or plant extracts | Deguelin | |
| PMID | 19861544 | |
| Literature evidence | A novel look into estrogen receptor-negative breast cancer prevention with the natural, multifunctional signal transduction inhibitor deguelin. | |
| IUPAC name | (1S,14S)-17,18-dimethoxy-7,7-dimethyl-2,8,21-trioxapentacyclo[12.8.0.03,12.04,9.015,20]docosa-3(12),4(9),5,10,15,17,19-heptaen-13-one | |
| Phytochemicals’ class or type of plant extracts | Rotenone | |
| Source of phytochemicals or plant Extracts | Mundulea sericea | |
| Geographical availability | Angola, Benin, Botswana, Cameroon, Caprivi Strip, Central African Repu, India, Ivory Coast, Kenya, KwaZulu-Natal, Madagascar, Malawi, Mozambique, Namibia, Nigeria, Northern Provinces, Somalia, Sri Lanka, Sudan, Swaziland, Tanzania, Togo, Uganda, Zambia, Zimbabwe | |
| Plant parts | NA | |
| Other cancers | Breast cancer | |
| Target gene or protein | NA | |
| Gene or Protein evidence | NA | |
| Target pathways | wnt/beta-catenin signaling | |
| IC50 | NA | |
| Potency | Our growing understanding of deguelin mechanisms could lead to important advances in the prevention of estrogen receptor-negative breast and other cancers. | |
| Cell line/ mice model | MDA-MB-231 | |
| Additional information | These investigators showed that deguelin inhibits wnt/beta-catenin signaling in breast cancer cell lines, in addition to inhibiting other previously reported signaling pathways. | |
| PubChem ID | 107935 | |
| Additional PMIDs | NA | |
| Additional sources of information | https://powo.science.kew.org/taxon/urn:lsid:ipni.org:names:509368-1 | |
| Safety | NA |