| Properties | Information | |
|---|---|---|
| PhytoCAT-ID | PhytoCAT-47 | |
| Phytochemical name or plant extracts | β-lapachone | |
| PMID | 30003778 | |
| Literature evidence | Isonapabucasin (7) turned out to be twice as potent against STAT3 as napabucasin (6) in the HTRF assay, with an EC50 in the submicromolar range, which was in excellent agreement with the potency of both agents to inhibit the growth of MDA-MB-231 cells. | |
| IUPAC name | 2,2-dimethyl-3,4-dihydrobenzo[h]chromene-5,6-dione | |
| Phytochemicals’ class or type of plant extracts | Naphthoquinone | |
| Source of phytochemicals or plant Extracts | Handroanthus impetiginosus | |
| Geographical availability | Argentina Northwest, Bolivia, Brazil North, Brazil Northeast, Brazil Southeast, Brazil West-Central, Colombia, Costa Rica, El Salvador, French Guiana, Guatemala, Honduras, Mexico Central, Mexico Southeast, Mexico Southwest, Nicaragua, Panamá, Paraguay, Peru, Suriname, Venezuela | |
| Plant parts | Bark | |
| Other cancers | Breast cancer, Leukemia | |
| Target gene or protein | NA | |
| Gene or Protein evidence | NA | |
| Target pathways | NA | |
| IC50 | 4.3 ± 0.44 μmol/L against MDA-MB-231 | |
| Potency | β-Lapachone (3) has been reported to effectively kill breast cancer cells by apoptosis, which was independent of the cell cycle status. | |
| Cell line/ mice model | K562, MDA-MB-231 | |
| Additional information | NA | |
| PubChem ID | 3885 | |
| Additional PMIDs | NA | |
| Additional sources of information | https://powo.science.kew.org/taxon/urn:lsid:ipni.org:names:117330-2 | |
| Safety | NA |