| Properties | Information | |
|---|---|---|
| PhytoCAT-ID | PhytoCAT-1201 | |
| Phytochemical name or plant extracts | Celastrol | |
| PMID | 25310109 | |
| Literature evidence | Taken together, our findings indicate that celastrol may be a potential candidate for breast cancer chemotherapy | |
| IUPAC name | (2R,4aS,6aR,6aS,14aS,14bR)-10-hydroxy-2,4a,6a,6a,9,14a-hexamethyl-11-oxo-1,3,4,5,6,13,14,14b-octahydropicene-2-carboxylic acid | |
| Phytochemicals’ class or type of plant extracts | Quinone methide Triterpenoid | |
| Source of phytochemicals or plant Extracts | Tripterygium wilfordii Hook F | |
| Geographical availability | China South-Central, China Southeast, Myanmar, Taiwan, Tibet, Vietnam | |
| Plant parts | NA | |
| Other cancers | Breast cancer | |
| Target gene or protein | CXCR4, NF- kB, MMP9, DCLK1, ALDH1, CD133 | |
| Gene or Protein evidence | Overall, these results show that celastrol has potential in suppressing invasion and metastasis of cancer cells by down-modulation of CXCR4 expression. These results indicate that celastrol inhibits NF-kB-mediated MMP-9 expression, resulting in suppression of breast cancer cell invasion and migration that is induced by PMA. Furthermore, the compound suppressed expression of cancer stem cell marker proteins DCLK1, ALDH1, and CD133. | |
| Target pathways | Overall, our results demonstrate that celastrol can potentiate the apoptotic effects of TRAIL through down-regulation of cell survival proteins and up-regulation of death receptors via the ROS-mediated up-regulation of CHOP pathway. | |
| IC50 | NA | |
| Potency | Taken together, our findings indicate that celastrol may be a potential candidate for breast cancer chemotherapy. | |
| Cell line/ mice model | MDA-MB-231, MCF-7 | |
| Additional information | Both celastrol or triptolide reduced Notch -1 activation and expression of its downstream target proteins HES-1 and HEY-1. | |
| PubChem ID | 122724 | |
| Additional PMIDs | 21786165 23266469 25310109 27159672 1842005 20934245 21134410 32920591 33924995 30588010 21865725 20798912 34170694 32483248 14640511 20154087 | |
| Additional sources of information | https://powo.science.kew.org/taxon/urn:lsid:ipni.org:names:162908-1 | |
| Safety | NA |