| Properties | Information | |
|---|---|---|
| PhytoCAT-ID | PhytoCAT-182 | |
| Phytochemical name or plant extracts | Eleutherine | |
| PMID | 26468762 | |
| Literature evidence | The naphthoquinone derivatives (eleutherine, isoeleutherine, and eleutherol) isolated from the bulbs of C. paludosa exhibited promising cytotoxicity against several human tumour cell lines, especially the two main compounds, eleutherine and isoeleutherine, against glioma and breast cancer cell lines, with TGI values of between 2.6 and 13.8 μg/mL. | |
| IUPAC name | NA | |
| Phytochemicals’ class or type of plant extracts | Quinone | |
| Source of phytochemicals or plant Extracts | Cipura paludosa | |
| Geographical availability | Belize, Bolivia, Brazil North, Brazil Northeast, Brazil Southeast, Brazil West-Central, Colombia, Costa Rica, Cuba, Dominican Republic, El Salvador, French Guiana, Guatemala, Honduras, Mexico Gulf, Mexico Southeast, Mexico Southwest, Nicaragua, Panamá, Paraguay, Peru, Trinidad-Tobago, Venezuela | |
| Plant parts | Bulbs and Root | |
| Other cancers | Breast cancer, Glioma, Lung cancer, Colon cancer, Kidney cancer | |
| Target gene or protein | NA | |
| Gene or Protein evidence | NA | |
| Target pathways | NA | |
| IC50 | NA | |
| Potency | TGI = 4.8 μg/mL against MCF-7 | |
| Cell line/ mice model | U251, MCF-7, NCI-ADR, 786-0, NCI-H460, HT29, K562, HaCat | |
| Additional information | The naphthoquinone derivatives (eleutherine, isoeleutherine, and eleutherol) isolated from the bulbs of C. paludosa exhibited promising cytotoxicity against several human tumour cell lines, especially the two main compounds, eleutherine and isoeleutherine, against glioma and breast cancer cell lines, with TGI values of between 2.6 and 13.8 μg/mL. | |
| PubChem ID | NA | |
| Additional PMIDs | NA | |
| Additional sources of information | https://powo.science.kew.org/taxon/urn:lsid:ipni.org:names:274679-2 | |
| Safety | NA |