| Properties | Information | |
|---|---|---|
| PhytoCAT-ID | PhytoCAT-46 | |
| Phytochemical name or plant extracts | Napabucasin | |
| PMID | 30003778 | |
| Literature evidence | Isonapabucasin (7) turned out to be twice as potent against STAT3 as napabucasin (6) in the HTRF assay, with an EC50 in the submicromolar range, which was in excellent agreement with the potency of both agents to inhibit the growth of MDA-MB-231 cells. | |
| IUPAC name | 2-acetylbenzo[f][1]benzofuran-4,9-dione | |
| Phytochemicals’ class or type of plant extracts | Naphthoquinone | |
| Source of phytochemicals or plant Extracts | Handroanthus impetiginosus | |
| Geographical availability | Argentina Northwest, Bolivia, Brazil North, Brazil Northeast, Brazil Southeast, Brazil West-Central, Colombia, Costa Rica, El Salvador, French Guiana, Guatemala, Honduras, Mexico Central, Mexico Southeast, Mexico Southwest, Nicaragua, Panamá, Paraguay, Peru, Suriname, Venezuela | |
| Plant parts | Bark | |
| Other cancers | Breast cancer, Leukemia | |
| Target gene or protein | STAT-3 | |
| Gene or Protein evidence | Napabucasin (6), as a previously described STAT3 inhibitor | |
| Target pathways | NA | |
| IC50 | 2.1 ± 0.09 μmol/L against MDA-MB-231 | |
| Potency | EC50 = 2.0 μmol/L | |
| Cell line/ mice model | K562, MDA-MB-231 | |
| Additional information | In a homogeneous time-resolved fluorescence (HTRF) assays with MDA-MB-231 cells, both napabucasin (6) and isonapabucasin (7) were identified as targeting STAT3 phosphorylation. | |
| PubChem ID | 10331844 | |
| Additional PMIDs | 31760402 34107166 | |
| Additional sources of information | https://powo.science.kew.org/taxon/urn:lsid:ipni.org:names:117330-2 | |
| Safety | NA |