| PhytoCAT-ID | Phytochemical name or plant extracts | Source of phytochemicals or plant Extracts | Target gene or protein | Cell line/ mice model |
|---|---|---|---|---|
| PhytoCAT-8 | 7′-methoxy-3′-O-demethyl-tanegool-9-O-β-d-glucopyranoside | Calotropis procera | NA | MCF-7, HCT-116, HepG-2, A-549 |
| PhytoCAT-101 | Terminaloside Q | Terminalia citrina | NA | MCF-7, T47D |
| PhytoCAT-102 | Terminaloside R | Terminalia citrina | NA | MCF-7, T47D |
| PhytoCAT-103 | Terminaloside S | Terminalia citrina | NA | MCF-7, T47D |
| PhytoCAT-104 | Terminaloside T | Terminalia citrina | NA | MCF-7, T47D |
| PhytoCAT-105 | Terminaloside U | Terminalia citrina | NA | MCF-7, T47D |
| PhytoCAT-106 | Terminaloside V | Terminalia citrina | NA | MCF-7, T47D |
| PhytoCAT-107 | Terminaloside W | Terminalia citrina | NA | MCF-7, T47D |
| PhytoCAT-191 | LXY6090 - a novel manassantin A derivative | Saururus cernuus | HIF-1, VEGF, IGF-2 | T47D, MCF-7 |
| PhytoCAT-216 | Deoxypodophyllotoxin | Juniperus communis | NA | MDA-MB-231 |
| PhytoCAT-557 | Secoisolariciresinol diglucoside | Linum usitatissium | ps2, Bcl-2, IGF-1R, ERα, ERbeta, EGFR, Bcl-2 mRNA, PMAPK protein, p65, NF-κB | C57BL/6 mice, E0771, MDA-MB-231, MCF-7 |
| PhytoCAT-570 | Gomisin H | Schisandra viridis | NA | MCF-7, CAL27, HEK293 |
| PhytoCAT-571 | Schisandrin | Schisandra viridis | NA | MCF-7, CAL27, HEK293 |
| PhytoCAT-572 | Angeloylgomisin H | Schisandra viridis | NA | MCF-7, CAL27, HEK293 |
| PhytoCAT-573 | (+)-gomisin M2 | Schisandra viridis | NA | MCF-7, CAL27, HEK293 |
| PhytoCAT-615 | Erythro-austrobailignan-6 (EA6) | Machilus thunbergii | HER2/EGFR/integrinβ3, topo II | MCF-7, 4T1 |
| PhytoCAT-616 | Meso-monomethyl dihydroguaiaretic acid | Machilus thunbergii | NA | MCF-7, HT-29 |
| PhytoCAT-617 | Meso-dihydroguaiaretic acid (MDGA) | Myristica argentea | EGFR,Src, CDK-4, cyclin D1, integrin β3 | MCF-7, 4T1, HT-29 |
| PhytoCAT-618 | Nectandrin-B | Myristica argentea | 17beta-hydroxysteroid dehydrogenase, Aromatase | MCF-7 |
| PhytoCAT-619 | (-)-Acuminatin | Machilus thunbergii | NA | MCF-7, HT-29 |
| PhytoCAT-652 | Gomisin J | Schisandra chinensis | p62, SQSTM1, LC3-I | MCF-7, MDA-MB-231, BT-20, BT-549, T47D, SKBR-3, MDA-MB-453, HS578T, MDA-MB-468, HCT116, HT-29, HeLa, SiHa |
| PhytoCAT-666 | Arctiin | Forsythia koreana | STAT3, TGF-β1, TLR4, NLRP3, VEGF, and cyclin D1 | MCF-7, HeLa, SiHa |
| PhytoCAT-937 | Ramonanin A | Guaiacum sanctum and Guaiacum officinale | NA | SKBR-3, MD-MBA-468, MD-MBA 231 |
| PhytoCAT-938 | Nordihydroguaiaretic acid (NDGA) | Larrea divaricata | p16INK4a | HepG2, MDA-MB-468, T47D, RKO |
| PhytoCAT-944 | Taiwanin E | Eleutherococcus trifoliatus | pRb, CDK4, p21, p27, CDK6, Cyclin D3, Cyclin D4 | MCF-7 |
| PhytoCAT-1102 | (+)-lariciresinol | Euterpe oleracea | NA | MCF-7 |
| PhytoCAT-1103 | (+)-pinoresinol | Euterpe oleracea | p53 | MCF-7, MDA-MB-231, HCT116, LNCaP |
| PhytoCAT-1104 | (+)-syringaresinol | Euterpe oleracea | NA | HeLa, Hep3B, MCF-7 |
| PhytoCAT-1110 | Arctigenin | Arctium lappa | 4EBP1, STAT-3, RAD51, Survivin, β-catenin, Cyclin D1 | MDA-MB-231, MCF-7 |
| PhytoCAT-1131 | Aviculin | Lespedeza cuneata | PARP, Caspase 9, Caspase 7, Bax, Bcl-2 | MCF-7 |
| PhytoCAT-1136 | Honokiol | Magnolia obovata | c-Src, EGFR, AKT, mTOR , 4E-BP and p70 S6 kinase, Caspase 3, Caspase 8, Caspase 9, Bid, Bcl-2, Neu1, NO, COX-2, NF-kB, IL-6, miR-188-5p, FBXW7 | Female Sprague Dawlely (SD) rats, MCF-7/ADR, MCF-7, 4T1, MDA-MB-231 |
| PhytoCAT-1138 | Magnolol | Magnolia officinalis | miR-200c | T47D, MCF-7, Hela, A549 |
| PhytoCAT-1180 | Schisandrin B | Schisandrae Chinensis | NOX4, TGF-β | 4T1, siha, MCF-7, A2780 |
| PhytoCAT-1181 | Schisandrin A | Schisandrae Chinensis | p65, STAT-3 | MDA-MB-231, BT-549, MDA-MB-231 xenograft mouse model |
| PhytoCAT-1271 | Flaxseed | Linum usitatissimum | Insulin-like growth factor I, Epidermal growth factor receptor | MCF-7, MDA-MB-435 and MDA-MB-231, SKBR-3, athymic mice with MCF-7 xenografts |
| PhytoCAT-1524 | Mappiodoinin A | Mappianthus iodoies | NA | HL-60, SMMC-7721, A-549, MCF-7 and SW-480 |
| PhytoCAT-1525 | Mappiodoinin B | Mappianthus iodoies | NA | HL-60, SMMC-7721, A-549, MCF-7 and SW-480 |
| PhytoCAT-1526 | Mappiodoinin C | Mappianthus iodoies | NA | HL-60, SMMC-7721, A-549, MCF-7 and SW-480 |
| PhytoCAT-1527 | Conocarpan | Mappianthus iodoies | NA | HL-60, SMMC-7721, A-549, MCF-7 and SW-480 |
| PhytoCAT-1528 | Odoratisol A | Mappianthus iodoies | NA | HL-60, SMMC-7721, A-549, MCF-7 and SW-480 |
| PhytoCAT-1529 | Trichobenzolignan | Mappianthus iodoies | NA | HL-60, SMMC-7721, A-549, MCF-7 and SW-480 |
| PhytoCAT-1530 | Prunustosanan AI | Mappianthus iodoies | NA | HL-60, SMMC-7721, A-549, MCF-7 and SW-480 |
| PhytoCAT-1531 | Simulanol | Mappianthus iodoies | NA | HL-60, SMMC-7721, A-549, MCF-7 and SW-480 |
| PhytoCAT-1532 | Woorenogenin | Mappianthus iodoies | NA | HL-60, SMMC-7721, A-549, MCF-7 and SW-480 |
| PhytoCAT-1534 | Cassyformin | Mappianthus iodoies | NA | HL-60, SMMC-7721, A-549, MCF-7 and SW-480 |
| PhytoCAT-1824 | Fevicordin-A (FevA) | Phaleria macrocarpa (Scheff) Boerl | NA | MCF-7, T47D |
| PhytoCAT-1857 | Sesamin | Sesamum indicum, Zanthoxylum capense, Zanthoxylum paracanthum Kokwaro, Peperomia pellucida, Zanthoxylum nitidum, Homalomena wendlandii, Stemona pierrei, Knema glauca, Triclisia sacleuxii, Zanthoxylum setulosum | CDK2, CDK4, CDK6, E2F1, PDK1, Bax, Caspase 3, p53 | MCF-7,+SA, MDA-MB-231, Caco-2, HEK295, mouse |
| PhytoCAT-1923 | Gomisin G | Schisandra chinesis | AKT phosphorylation, retinoblastoma tumor suppressor (Rb), phosphorylated Rb, Cyclin D1 | MDA-MB-231 and MDA-MB-468 |
| PhytoCAT-1947 | (+)-pinoresinol di-O-β-d-allopyranoside | Cimicifuga dahurica (Turcz.) Maxim. | c-Myc, Cyclin D1, Bcl-2 | MCF-7 |
| PhytoCAT-1964 | 3-(1, 3-benzodioxol-5-ylmethyl)-4-[(3, 4-dimethoxyphenyl)methyl]dihydro-, (3S-cis)-2(3H)-furanone | Wikstroemia scytophylla | NA | HL-60, SMMC-7721, A549, MCF-7, and SW480 |
| PhytoCAT-1965 | 4-[(R)-1, 3-benzodioxol-5-ylhydroxymethyl]-3-(1, 3-benzodioxol-5-ylmethyl)dihydro-, (3S, 4R)-2(3H)-furanone | Wikstroemia scytophylla | NA | HL-60, SMMC-7721, A549, MCF-7, and SW480 |
| PhytoCAT-1966 | (-)-dihydrosesamin | Wikstroemia scytophylla | NA | HL-60, SMMC-7721, A549, MCF-7, and SW480 |
| PhytoCAT-1967 | 4, 4’-dihydroxy-3, 3’, 9-trimethoxy-9, 9’-epoxylignan | Wikstroemia scytophylla | NA | HL-60, SMMC-7721, A549, MCF-7, and SW480 |
| PhytoCAT-1968 | (+)-1-hydroxypinoresinol | Wikstroemia scytophylla | NA | HL-60, SMMC-7721, A549, MCF-7, and SW480 |