| Properties | Information | |
|---|---|---|
| PhytoCAT-ID | PhytoCAT-1534 | |
| Phytochemical name or plant extracts | Cassyformin | |
| PMID | 29040842 | |
| Literature evidence | Neolignans 1-12 showed significant cytotoxic effects against various human cancer cell lines with IC50 values ranging from 0.16 to 18.62 μM. | |
| IUPAC name | (E)-3-[(2R,3S)-2-(3,4-dihydroxy-5-methoxyphenyl)-3-(hydroxymethyl)-7-methoxy-2,3-dihydro-1-benzofuran-5-yl]prop-2-enal | |
| Phytochemicals’ class or type of plant extracts | Dihydrobenzofuran neolignan | |
| Source of phytochemicals or plant Extracts | Mappianthus iodoies | |
| Geographical availability | China South-Central, China Southeast, Hainan, Vietnam | |
| Plant parts | Leaves and stem | |
| Other cancers | Breast cancer, Leukemia, Liver cancer, Lung cancer, Colon cancer | |
| Target gene or protein | NA | |
| Gene or Protein evidence | NA | |
| Target pathways | NA | |
| IC50 | 17.49 ± 0.18 µM against MCF-7 | |
| Potency | The cytotoxicities against several human cancer cell lines of 1-12 were also investigated, and found to be quite potent, which may be used as an explanation of the folk use of M. iodoies, which had been used to treat tumors in China. | |
| Cell line/ mice model | HL-60, SMMC-7721, A-549, MCF-7 and SW-480 | |
| Additional information | Lignans and Neolignans with Antioxidant and Human Cancer Cell Proliferation Inhibitory Activities from Cinnamomum bejolghota Confirm Its Functional Food Property. | |
| PubChem ID | 145709329 | |
| Additional PMIDs | NA | |
| Additional sources of information | Tropical.theferns | |
| Safety | NA |