| Properties | Information | |
|---|---|---|
| PhytoCAT-ID | PhytoCAT-102 | |
| Phytochemical name or plant extracts | Terminaloside R | |
| PMID | 29149663 | |
| Literature evidence | α-Keto tetrahydrofuran lignan glucosides from the Bangladeshi medicinal plant Terminalia citrina inhibit estradiol (E2) induced proliferation in cancer cells. | |
| IUPAC name | NA | |
| Phytochemicals’ class or type of plant extracts | α-keto tetrahydrofuran lignan glucoside | |
| Source of phytochemicals or plant Extracts | Terminalia citrina | |
| Geographical availability | Andaman Is., Assam, Bangladesh, Borneo, East Himalaya, India, Jawa, Laos, Lesser Sunda Is., Malaya, Maluku, Myanmar, Nepal, Nicobar Is., Philippines, Sulawesi, Sumatera, Thailand, Vietnam, West Himalaya | |
| Plant parts | Leaves | |
| Other cancers | Breast cancer | |
| Target gene or protein | NA | |
| Gene or Protein evidence | NA | |
| Target pathways | NA | |
| IC50 | NA | |
| Potency | iEqE50 = <0.01 μM against MCF-7 and T47D. More than 90% inhibition with the concentration tested in T47D | |
| Cell line/ mice model | MCF-7, T47D | |
| Additional information | Terminaloside R, which has a dioxymethylene group in its aromatic ring, inhibited 90% of estradiol-enhanced cell proliferation in T47D and MCF-7 cells at concentrations of 0.01 μM and 0.1 μM, respectively. | |
| PubChem ID | NA | |
| Additional PMIDs | NA | |
| Additional sources of information | https://powo.science.kew.org/taxon/urn:lsid:ipni.org:names:171050-1 | |
| Safety | NA |