| Properties | Information | |
|---|---|---|
| PhytoCAT-ID | PhytoCAT-666 | |
| Phytochemical name or plant extracts | Arctiin | |
| PMID | 12672988 | |
| Literature evidence | Compound 6 showed the most potent proliferative effect on the growth of MCF-7 human breast cancer cells in culture among 1 and six metabolites, while it showed inhibitory activity on estradiol-mediated proliferation of MCF-7 cells at a concentration of 10 microM. | |
| IUPAC name | (3R,4R)-4-[(3,4-dimethoxyphenyl)methyl]-3-[[3-methoxy-4-[(2S,3R,4S,5S,6R)-3,4,5-trihydroxy-6-(hydroxymethyl)oxan-2-yl]oxyphenyl]methyl]oxolan-2-one | |
| Phytochemicals’ class or type of plant extracts | Lignan | |
| Source of phytochemicals or plant Extracts | Forsythia koreana | |
| Geographical availability | Korea | |
| Plant parts | Fruits | |
| Other cancers | Breast cancer and Cervical cancer | |
| Target gene or protein | STAT3, TGF-β1, TLR4, NLRP3, VEGF, and cyclin D1 | |
| Gene or Protein evidence | Additional research has shown that arctiin is able to suppress inflammation, fibrosis, and the migration of tumor cells by inhibiting STAT3, TGF-β1, TLR4, NLRP3, VEGF, and cyclin D1. | |
| Target pathways | NA | |
| IC50 | NA | |
| Potency | NA | |
| Cell line/ mice model | MCF-7, HeLa, SiHa | |
| Additional information | Arctiin inhibits cervical cancer cell migration and invasion through suppression of S100A4 and the PI3K/Akt pathway. | |
| PubChem ID | 100528 | |
| Additional PMIDs | 23659170 21031625 12672988 37701157 35214097 | |
| Additional sources of information | https://powo.science.kew.org/taxon/urn:lsid:ipni.org:names:608893-1 | |
| Safety | NA |