| Properties | Information | |
|---|---|---|
| PhytoCAT-ID | PhytoCAT-1181 | |
| Phytochemical name or plant extracts | Schisandrin A | |
| PMID | 31048190 | |
| Literature evidence | In this study, we evaluated the toxic potential of schisandrin A (SchA), a bioactive phytochemical found in Schisandra chinensis in TNBC. | |
| IUPAC name | (9R,10S)-3,4,5,14,15,16-hexamethoxy-9,10-dimethyltricyclo[10.4.0.02,7]hexadeca-1(16),2,4,6,12,14-hexaene | |
| Phytochemicals’ class or type of plant extracts | Lignan | |
| Source of phytochemicals or plant Extracts | Schisandrae Chinensis | |
| Geographical availability | Amur, China North-Central, Inner Mongolia, Japan, Khabarovsk, Korea, Manchuria, Primorye, Sakhalin | |
| Plant parts | Fruits | |
| Other cancers | Breast cancer | |
| Target gene or protein | p65, STAT-3 | |
| Gene or Protein evidence | SchA has been found to reverse doxorubicin-resistant human breast cancer cells (MCF-7/Dox cells) by inhibition of P65 and Stat3 phosphorylation | |
| Target pathways | Wnt/ER stress signaling pathway | |
| IC50 | 41.43 ± 1.45 μM against MDA-MB-231 134.21 ± 6.85 μM against BT-549 | |
| Potency | All of these data indicate that SchA could be a potential candidate for the treatment of TNBC. | |
| Cell line/ mice model | MDA-MB-231, BT-549, MDA-MB-231 xenograft mouse model | |
| Additional information | SchA has been proved to enhance chemosensitivity of colon cancer cells to 5-fluorouracil through up-regulation of miR-195 | |
| PubChem ID | 155256 | |
| Additional PMIDs | NA | |
| Additional sources of information | https://powo.science.kew.org/taxon/urn:lsid:ipni.org:names:60456331-2 | |
| Safety | NA |