| Properties | Information | |
|---|---|---|
| PhytoCAT-ID | PhytoCAT-652 | |
| Phytochemical name or plant extracts | Gomisin J | |
| PMID | 30542721 | |
| Literature evidence | In attempting to identify effective anticancer drugs from natural products that are harmless to humans, we found that the gomisin J from Schisandra chinensis fruit has anticancer activity. | |
| IUPAC name | (9R,10S)-3,4,15,16-tetramethoxy-9,10-dimethyltricyclo[10.4.0.02,7]hexadeca-1(16),2,4,6,12,14-hexaene-5,14-diol | |
| Phytochemicals’ class or type of plant extracts | Lignan | |
| Source of phytochemicals or plant Extracts | Schisandra chinensis | |
| Geographical availability | Amur, China North-Central, Inner Mongolia, Japan, Khabarovsk, Korea, Manchuria, Primorye, Sakhalin | |
| Plant parts | Fruit | |
| Other cancers | Breast cancer, Colon cancer, Cervical cancer | |
| Target gene or protein | p62, SQSTM1, LC3-I | |
| Gene or Protein evidence | Gomisin J treatment started to only slightly induce the decrease of p62/SQSTM1 expression level and the conversion from LC3-I to LC3-II after 24 h, but significantly after longer exposure of 72 h | |
| Target pathways | PI3K/AKT/mTOR pathway | |
| IC50 | NA | |
| Potency | In an extended study, gomisin J exhibited a strong cytotoxic effect on all tested various types of 13 cancer cell lines, indicating its potential to be used against a wide range of different types of cancer cells. | |
| Cell line/ mice model | MCF-7, MDA-MB-231, BT-20, BT-549, T47D, SKBR-3, MDA-MB-453, HS578T, MDA-MB-468, HCT116, HT-29, HeLa, SiHa | |
| Additional information | Our data also revealed that gomisin J induced necroptosis, a programmed form of necrosis, as well as apoptosis. Notably, gomisin J predominantly induced necroptosis in MCF7 cells that are known to have high resistance to many pro-apoptotic anticancer drugs, while MDA-MB-231 exhibited a much lower level of necroptosis but instead a higher level of apoptosis. | |
| PubChem ID | 3001686 | |
| Additional PMIDs | NA | |
| Additional sources of information | https://powo.science.kew.org/taxon/urn:lsid:ipni.org:names:60456331-2 | |
| Safety | Our data revealed that gomisin J exerted a much stronger cytotoxic effect on MCF7 and MDA-MB-231 cancer cells than on MCF10A normal cells. |