| Properties | Information | |
|---|---|---|
| PhytoCAT-ID | PhytoCAT-557 | |
| Phytochemical name or plant extracts | Secoisolariciresinol diglucoside | |
| PMID | 20432175 | |
| Literature evidence | Flaxseed (FS), an oilseed containing high amounts of the phytoestrogen lignan, secoisolariciresinol diglucoside (SDG), and n-3 fatty acid, alpha-linolenic acid-rich oil (FO), has been shown to inhibit the growth of established human breast tumors (MCF-7) in ovariectomized (OVX) athymic mice. | |
| IUPAC name | (2R,3R,4S,5S,6R)-2-[(2R,3R)-2,3-bis[(4-hydroxy-3-methoxyphenyl)methyl]-4-[(2R,3R,4S,5S,6R)-3,4,5-trihydroxy-6-(hydroxymethyl)oxan-2-yl]oxybutoxy]-6-(hydroxymethyl)oxane-3,4,5-triol | |
| Phytochemicals’ class or type of plant extracts | Lignan | |
| Source of phytochemicals or plant Extracts | Linum usitatissium | |
| Geographical availability | Iran, Iraq, Lebanon-Syria, North Caucasus, Transcaucasus, Turkey | |
| Plant parts | Seeds | |
| Other cancers | Breast cancer | |
| Target gene or protein | ps2, Bcl-2, IGF-1R, ERα, ERbeta, EGFR, Bcl-2 mRNA, PMAPK protein, p65, NF-κB | |
| Gene or Protein evidence | SDG alone also lowered the ERalpha, ERbeta, EGFR, BCL2 mRNA, and PMAPK protein, indicating that its effect involves the modulation of the ER- and growth factor receptor-mediated signaling pathways. SDG supplementation in the mice significantly reduced tumor volume and expression of phospho-p65 and NF-κB target genes SDG had a main effect in the reduction of PS2, BCL2, and IGF-1R mRNA expression | |
| Target pathways | NF-κB signaling | |
| IC50 | NA | |
| Potency | NA | |
| Cell line/ mice model | C57BL/6 mice, E0771, MDA-MB-231, MCF-7 | |
| Additional information | NA | |
| PubChem ID | 9917980 | |
| Additional PMIDs | 16549449 30367332 18444157 31689992 32510147 12672988 22136581 32312713 33025821 20432175 | |
| Additional sources of information | https://powo.science.kew.org/taxon/urn:lsid:ipni.org:names:544772-1 | |
| Safety | NA |