| Properties | Information | |
|---|---|---|
| PhytoCAT-ID | PhytoCAT-1131 | |
| Phytochemical name or plant extracts | Aviculin | |
| PMID | 32276430 | |
| Literature evidence | Of these, aviculin (2), a lignan glycoside, was the only compound that reduced metabolic activity on MCF-7 cells below 50% (IC50: 75.47 ± 2.23 μM). | |
| IUPAC name | (2R,3R,4R,5R,6S)-2-[[(1S,2R,3R)-7-hydroxy-1-(4-hydroxy-3-methoxyphenyl)-3-(hydroxymethyl)-6-methoxy-1,2,3,4-tetrahydronaphthalen-2-yl]methoxy]-6-methyloxane-3,4,5-triol | |
| Phytochemicals’ class or type of plant extracts | Lignan glycoside | |
| Source of phytochemicals or plant Extracts | Lespedeza cuneata | |
| Geographical availability | Afghanistan, Assam, China North-Central, China South-Central, China Southeast, East Himalaya, India, Japan, Jawa, Korea, Laos, Lesser Sunda Is., Malaya, Myanmar, Nansei-shoto, Nepal, New Guinea, New South Wales, Pakistan, Philippines, Queensland, Sumatera, Taiwan, Thailand, Tibet, Victoria, Vietnam, West Himalaya | |
| Plant parts | Aerial portion | |
| Other cancers | Breast cancer | |
| Target gene or protein | PARP, Caspase 9, Caspase 7, Bax, Bcl-2 | |
| Gene or Protein evidence | Aviculin (2) was found to induce apoptotic cell death through the intrinsic apoptosis pathway, as indicated by the increased expression of initiator caspase-9, executioner caspase-7, and poly (ADP-ribose) polymerase (PARP). Aviculin (2)-induced apoptotic cell death was accompanied by an increase in the Bax/Bcl-2 ratio. | |
| Target pathways | Aviculin (2) was found to induce apoptotic cell death through the intrinsic apoptosis pathway. | |
| IC50 | 75.47 ± 2.23 μM against MCF-7 | |
| Potency | aviculin (2) could induce breast cancer cell apoptosis through the intrinsic apoptosis pathway, and it can therefore be considered an excellent candidate for herbal treatment of breast cancer. | |
| Cell line/ mice model | MCF-7 | |
| Additional information | A previous study reported that aviculin isolated from Scurrula atropurpurea (Loranthaceae) inhibited cancer cell invasion in MM1 rat mesothelial cells | |
| PubChem ID | 10391477 | |
| Additional PMIDs | NA | |
| Additional sources of information | https://powo.science.kew.org/taxon/urn:lsid:ipni.org:names:502431-1 | |
| Safety | NA |