| Properties | Information | |
|---|---|---|
| PhytoCAT-ID | PhytoCAT-937 | |
| Phytochemical name or plant extracts | Ramonanin A | |
| PMID | 21391655 | |
| Literature evidence | The ramonanins exhibit cytotoxic activity against human breast cancer cell lines with an IC50 value of 18 μM and induce cell death via apoptotic mechanisms. | |
| IUPAC name | NA | |
| Phytochemicals’ class or type of plant extracts | Spirocyclic lignan | |
| Source of phytochemicals or plant Extracts | Guaiacum sanctum and Guaiacum officinale | |
| Geographical availability | Aruba, Bahamas, Belize, Costa Rica, Cuba, Dominican Republic, El Salvador, Florida, Guatemala, Haiti, Honduras, Mexico Gulf, Mexico Southeast, Mexico Southwest, Netherlands Antilles, Nicaragua, Panamá, Puerto Rico, Turks-Caicos Is. | |
| Plant parts | Heartwood | |
| Other cancers | Breast cancer | |
| Target gene or protein | NA | |
| Gene or Protein evidence | NA | |
| Target pathways | NA | |
| IC50 | 18 μM against MDA-MB-231 | |
| Potency | The ramonanins exhibit cytotoxic activity against human breast cancer cell lines with an IC50 value of 18 μM and induce cell death via apoptotic mechanisms. | |
| Cell line/ mice model | SKBR-3, MD-MBA-468, MD-MBA 231 | |
| Additional information | Cytotoxicity of the G. sanctum chloroform extracts was further characterized using sulforhodamine B (SRB) assays, which indicated strong antiproliferative activity with an IC50 of 20 μg/mL for human breast cancer cell line MB-MDA 231. Analysis of MB-MDA 231 cells treated with G. sanctum extract at 20 μg/mL by fluorescence microscopy after staining with Hoechst 33342 and propidium iodide revealed 70% apoptotic cell death after 12 h of exposure. | |
| PubChem ID | NA | |
| Additional PMIDs | NA | |
| Additional sources of information | https://powo.science.kew.org/taxon/urn:lsid:ipni.org:names:873256-1 | |
| Safety | NA |