| Properties | Information | |
|---|---|---|
| PhytoCAT-ID | PhytoCAT-618 | |
| Phytochemical name or plant extracts | Nectandrin-B | |
| PMID | 11731908 | |
| Literature evidence | Three of them, erythro-austrobailignan-6, meso-dihydroguaiaretic acid and nectandrin-B, exert an antiproliferative effect on MCF-7 cells as well as antioxidant activity on the 1,1-diphenyl-2-picrylhydrazyl (DPPH) radical, but not the threo-austrobailignan-5. | |
| IUPAC name | 4-[(2R,3R,4S,5S)-5-(4-hydroxy-3-methoxyphenyl)-3,4-dimethyloxolan-2-yl]-2-methoxyphenol | |
| Phytochemicals’ class or type of plant extracts | Lignan | |
| Source of phytochemicals or plant Extracts | Myristica argentea | |
| Geographical availability | New Guinea | |
| Plant parts | Mace | |
| Other cancers | Breast cancer | |
| Target gene or protein | 17beta-hydroxysteroid dehydrogenase, Aromatase | |
| Gene or Protein evidence | Nectandrin-B also possesses anti-17beta-hydroxysteroid dehydrogenase and anti-aromatase activities. | |
| Target pathways | NA | |
| IC50 | NA | |
| Potency | NA | |
| Cell line/ mice model | MCF-7 | |
| Additional information | NecB may hold promise as a potential therapeutic agent for promoting longevity and addressing age-related degeneration. | |
| PubChem ID | 156517 | |
| Additional PMIDs | 37983180 | |
| Additional sources of information | https://powo.science.kew.org/taxon/urn:lsid:ipni.org:names:585972-1 | |
| Safety | NA |