| Properties | Information | |
|---|---|---|
| PhytoCAT-ID | PhytoCAT-1138 | |
| Phytochemical name or plant extracts | Magnolol | |
| PMID | 24147344 | |
| Literature evidence | Further mechanistic studies revealed that induction of apoptosis is associated with cell cycle arrest at G2/M phase, increased generation of reactive oxygen species (ROS), reduced mitochondrial membrane potential (MMP), release of cytochrome c (Cyto c) and apoptosis inducing factor (AIF) from mitochondria to cytosol, upregulation of Bax, p21 and p53, and down-regulation of Bcl-2, cyclin B1 and cyclin-dependent kinase 1 (CDK1). | |
| IUPAC name | 2-(2-hydroxy-5-prop-2-enylphenyl)-4-prop-2-enylphenol | |
| Phytochemicals’ class or type of plant extracts | Neolignan | |
| Source of phytochemicals or plant Extracts | Magnolia officinalis | |
| Geographical availability | China North-Central, China South-Central, China Southeast, Tibet | |
| Plant parts | Root and Stem | |
| Other cancers | Breast cancer, Cervical cancer, Lung Cancer | |
| Target gene or protein | miR-200c | |
| Gene or Protein evidence | By screening a library containing 139 natural substances, three natural compounds - enoxolone, magnolol and palmatine chloride - were identified as being capable of inducing miR-200c expression in breast cancer cells at 10 μM. | |
| Target pathways | Our findings indicated that magnolol induced apoptosis in MCF-7 cells via the intrinsic pathway with release of AIF from mitochondrial and G2/M phase arrest pathway. | |
| IC50 | NA | |
| Potency | Therefore, magnolol might be a potential lead compound in the therapy of breast cancer. | |
| Cell line/ mice model | T47D, MCF-7, Hela, A549 | |
| Additional information | NA | |
| PubChem ID | 72300 | |
| Additional PMIDs | 30884326 24147344 24226295 26423775 32791403 | |
| Additional sources of information | https://powo.science.kew.org/taxon/urn:lsid:ipni.org:names:554787-1 | |
| Safety | NA |