| Properties | Information | |
|---|---|---|
| PhytoCAT-ID | PhytoCAT-1271 | |
| Phytochemical name or plant extracts | Flaxseed | |
| PMID | 16557589 | |
| Literature evidence | SP initially regressed the tumors but starting at week 13, the tumors regressed significantly less than in control and 43% of the tumors were regrowing until the end of the experiment and were significantly larger in size than in control. | |
| IUPAC name | (2R,3R)-2,3-bis[(4-hydroxy-3-methoxyphenyl)methyl]butane-1,4-diol,(2R,3R,4S,5S,6R)-6-(hydroxymethyl)oxane-2,3,4,5-tetrol | |
| Phytochemicals’ class or type of plant extracts | Lignan | |
| Source of phytochemicals or plant Extracts | Linum usitatissimum | |
| Geographical availability | Iran, Iraq, Lebanon-Syria, North Caucasus, Transcaucasus, Turkey | |
| Plant parts | Seeds | |
| Other cancers | Breast cancer | |
| Target gene or protein | Insulin-like growth factor I, Epidermal growth factor receptor | |
| Gene or Protein evidence | In conclusion, flaxseed inhibited the established human breast cancer growth and metastasis in a nude mice model, and this effect is partly due to its downregulation of insulin-like growth factor I and epidermal growth factor receptor expression. | |
| Target pathways | Dietary flaxseed interaction with tamoxifen induced tumor regression in athymic mice with MCF-7 xenografts by downregulating the expression of estrogen related gene products and signal transduction pathways. | |
| IC50 | NA | |
| Potency | These results indicate that flaxseed oil can specifically inhibit cancer cell growth and induce apoptosis in some cancer cells and suggests it has further potential in anti-cancer therapy. | |
| Cell line/ mice model | MCF-7, MDA-MB-435 and MDA-MB-231, SKBR-3, athymic mice with MCF-7 xenografts | |
| Additional information | Our in vitro evaluation suggests a future direction in improving chemotherapeutic efficacy in breast cancer by adjuvant therapy with the flaxseed lignans. In conclusion, flaxseed inhibited the established human breast cancer growth and metastasis in a nude mice model, and this effect is partly due to its downregulation of insulin-like growth factor I and epidermal growth factor receptor expression. Flaxseed may be unsafe during pregnancy as it may have mild hormonal effects, but there is no reliable research on flaxseed’s effects on pregnancy outcomes. Some research suggests that flaxseed oil taken in the second or third trimester of pregnancy may increase the chance of premature births. | |
| PubChem ID | 164475 | |
| Additional PMIDs | 31440598 16549449 29303360 12588699 17640162 15570004 | |
| Additional sources of information | https://powo.science.kew.org/taxon/urn:lsid:ipni.org:names:544772-1 | |
| Safety | NA |