| Properties | Information | |
|---|---|---|
| PhytoCAT-ID | PhytoCAT-1180 | |
| Phytochemical name or plant extracts | Schisandrin B | |
| PMID | 28827665 | |
| Literature evidence | Our results showed that Sch B increased the intracellular accumulation of DOX through inhibiting expression and activity of P-glycoprotein (P-gp). | |
| IUPAC name | 3,4,5,19-tetramethoxy-9,10-dimethyl-15,17-dioxatetracyclo[10.7.0.02,7.014,18]nonadeca-1(19),2,4,6,12,14(18)-hexaene | |
| Phytochemicals’ class or type of plant extracts | Lignan | |
| Source of phytochemicals or plant Extracts | Schisandrae Chinensis | |
| Geographical availability | Amur, China North-Central, Inner Mongolia, Japan, Khabarovsk, Korea, Manchuria, Primorye, Sakhalin | |
| Plant parts | NA | |
| Other cancers | Breast cancer, Cervical cancer | |
| Target gene or protein | NOX4, TGF-β | |
| Gene or Protein evidence | Sch B suppresses TGF-β-induced and NOX4-associated ROS production in 4T1 cells and inhibits TGF-β-enhanced cell migration. | |
| Target pathways | NA | |
| IC50 | NA | |
| Potency | Meanwhile, Sch B was identified as a potent P-gp inhibitor and could enhance DOX-induced apoptosis in cancer cells, but not in primary rat cardiomyocytes and primary human fibroblasts | |
| Cell line/ mice model | 4T1, siha, MCF-7, A2780 | |
| Additional information | Furthermore, Sch B preferentially promoted chymotryptic activity of the proteasome in a concentration-dependent manner, and the proteasome inhibitor MG-132 prevented Sch B-induced survivin downregulation. Taken together, our findings suggest that Sch B could be a potential candidate for combating drug resistant cancer via modulating two key factors that responsible for cancer resistance. | |
| PubChem ID | 108130 | |
| Additional PMIDs | 28827665 23688500 | |
| Additional sources of information | https://powo.science.kew.org/taxon/urn:lsid:ipni.org:names:60456331-2 | |
| Safety | Schisandrin B (Sch B), a naturally occurring dibenzocyclooctadiene lignan with very low toxicity, is a novel NOX inhibitor and its IC50 toward NOX4 is 9.3μM |