Phytochemical Name : Deoxypodophyllotoxin

Properties Information
PhytoCAT-ID PhytoCAT-216
Phytochemical name or plant extracts Deoxypodophyllotoxin
PMID 24913660
Literature evidence Our findings emphasize the potential and importance of natural product screening for new chemical entities with novel anticancer activities.
IUPAC name (5R,5aR,8aR)-5-(3,4,5-trimethoxyphenyl)-5a,8,8a,9-tetrahydro-5H-[2]benzofuro[5,6-f][1,3]benzodioxol-6-one
Phytochemicals’ class or type of plant extracts Aryltetralin lignan
Source of phytochemicals or plant Extracts Juniperus communis
Geographical availability Afghanistan, Alabama, Alaska, Albania, Algeria, Altay, Amur, Arizona, Austria, Baltic States, Belarus, Belgium, British Columbia, Bulgaria, Buryatiya, California, Central European Rus, Chita, Colorado, Connecticut, Corse, Cyprus, Czechoslovakia, Denmark, East Aegean Is., East European Russia, Finland, France, Føroyar, Georgia, Germany, Great Britain, Greece, Greenland, Hungary, Iceland, Idaho, Illinois, Indiana, Inner Mongolia, Iowa, Iran, Iraq, Ireland, Irkutsk, Italy, Japan, Kamchatka, Kazakhstan, Kentucky, Khabarovsk, Kirgizstan, Korea, Krasnoyarsk, Krym, Kuril Is., Labrador, Lebanon-Syria, Magadan, Maine, Manchuria, Maryland, Massachusetts, Michigan, Minnesota, Mongolia, Montana, Morocco, Nebraska, Nepal, Netherlands, Nevada, New Brunswick, New Hampshire, New Jersey, New Mexico, New York, Newfoundland, North Carolina, North Caucasus, North Dakota, North European Russi, Northwest European R, Northwest Territorie, Norway, Nova Scotia, Nunavut, Ohio, Ontario, Oregon, Pakistan, Pennsylvania, Poland, Portugal, Primorye, Prince Edward I., Québec, Rhode I., Romania, Sakhalin, Sardegna, Sicilia, South Carolina, South Dakota, South European Russi, Spain, Sweden, Switzerland, Tadzhikistan, Tennessee, Transcaucasus, Turkey, Turkey-in-Europe, Turkmenistan, Tuva, Ukraine, Utah, Uzbekistan, Vermont, Virginia, Washington, West Himalaya, West Siberia, West Virginia, Wisconsin, Wyoming, Xinjiang, Yakutskiya, Yugoslavia, Yukon
Plant parts NA
Other cancers NA
Target gene or protein NA
Gene or Protein evidence NA
Target pathways MAPK/ERK and NF-κB signaling pathways
IC50 NA
Potency Further elucidation revealed that DPT, in contrast to isocupressic acid, also concomitantly inhibited cell survival pathways mediated by the MAPK/ERK and NFκB signaling pathways within hours of treatment.
Cell line/ mice model MDA-MB-231
Additional information  NA
PubChem ID 345501
Additional PMIDs NA
Additional sources of information https://powo.science.kew.org/taxon/urn:lsid:ipni.org:names:30088655-2
Safety NA