| Properties | Information | |
|---|---|---|
| PhytoCAT-ID | PhytoCAT-1110 | |
| Phytochemical name or plant extracts | Arctigenin | |
| PMID | 32565252 | |
| Literature evidence | KEY FINDINGS: The experimental results show that Arc did not induce apoptosis in ER-positive breast cancer cell, rather caused G1 cycle arrest by decreasing cyclin D1 levels without effect on altering CDK4/6 levels. | |
| IUPAC name | (3R,4R)-4-[(3,4-dimethoxyphenyl)methyl]-3-[(4-hydroxy-3-methoxyphenyl)methyl]oxolan-2-one | |
| Phytochemicals’ class or type of plant extracts | Lignan | |
| Source of phytochemicals or plant Extracts | Arctium lappa | |
| Geographical availability | Afghanistan, Albania, Altay, Austria, Baleares, Baltic States, Belarus, Belgium, Bulgaria, Cambodia, Central European Rus, China North-Central, China South-Central, China Southeast, Corse, Cyprus, Czechoslovakia, Denmark, East Aegean Is., East European Russia, East Himalaya, Finland, France, Føroyar, Germany, Greece, Greenland, Hainan, Hungary, Iceland, Inner Mongolia, Iran, Iraq, Italy, Japan, Kazakhstan, Kirgizstan, Korea, Krasnoyarsk, Kriti, Krym, Laos, Lebanon-Syria, Malaya, Manchuria, Myanmar, Nepal, Netherlands, North Caucasus, North European Russi, Northwest European R, Norway, Pakistan, Palestine, Poland, Portugal, Qinghai, Romania, Sardegna, Sicilia, Sinai, South European Russi, Spain, Svalbard, Sweden, Switzerland, Tadzhikistan, Taiwan, Tibet, Transcaucasus, Turkey, Turkey-in-Europe, Turkmenistan, Ukraine, Uzbekistan, Vietnam, West Himalaya, West Siberia, Xinjiang, Yugoslavia | |
| Plant parts | NA | |
| Other cancers | Breast cancer | |
| Target gene or protein | 4EBP1, STAT-3, RAD51, Survivin, β-catenin, Cyclin D1 | |
| Gene or Protein evidence | Arctigenin inhibits human breast cancer cell proliferation, migratory and invasive abilities and epithelial to mesenchymal transition by targeting 4EBP1. ATG enhanced DOX-induced DNA damage and decreased the phosphorylation of signal transducer and activator of transcription 3 (STAT3) and the expressions of RAD51 and survivin. Arctigenin induced apoptosis and decreased expression of total and unphosphorylated (active) β-catenin and cyclin D1 in MCF-7, but not in MDA-MB-231. | |
| Target pathways | Arctigenin, a dietary phytoestrogen, induces apoptosis of estrogen receptor-negative breast cancer cells through the ROS/p38 MAPK pathway and epigenetic regulation. | |
| IC50 | NA | |
| Potency | These findings warrant the potential of Arc as a candidate treatment for ER-positive breast cancer. | |
| Cell line/ mice model | MDA-MB-231, MCF-7 | |
| Additional information | Arctigenin suppressed the expression of peroxisome proliferator-activated receptor-gamma (PPARγ), CCAAT/enhancer-binding protein-alpha (C/EBPα), perilipin, and fatty acid binding protein 4 (FABP4) in a dose-dependent manner in differentiated 3T3-L1 cells. Moreover, we have demonstrated that Arc decreases cyclin D1 levels through prompting Akt/GSK3β-mediated degradation. | |
| PubChem ID | 64981 | |
| Additional PMIDs | 28035371 28279068 32565252 32340377 24140706 27878294 33850519 23659170 27539316 21031625 27262066 21429215 12672988 | |
| Additional sources of information | https://powo.science.kew.org/taxon/urn:lsid:ipni.org:names:178385-1 | |
| Safety | NA |