| Properties | Information | |
|---|---|---|
| PhytoCAT-ID | PhytoCAT-1923 | |
| Phytochemical name or plant extracts | Gomisin G | |
| PMID | 29587339 | |
| Literature evidence | To investigate the molecular mechanism of this activity, we examined the signal transduction pathways after treatment with Gomisin G in MDA-MB-231 cells. | |
| IUPAC name | [(9S,10S,11S)-10-hydroxy-3,4,5,19-tetramethoxy-9,10-dimethyl-15,17-dioxatetracyclo[10.7.0.02,7.014,18]nonadeca-1(19),2,4,6,12,14(18)-hexaen-11-yl] benzoate | |
| Phytochemicals’ class or type of plant extracts | Lignan | |
| Source of phytochemicals or plant Extracts | Schisandra chinesis | |
| Geographical availability | Amur, China North-Central, Inner Mongolia, Japan, Khabarovsk, Korea, Manchuria, Primorye, Sakhalin | |
| Plant parts | Fruits | |
| Other cancers | Breast cancer | |
| Target gene or protein | AKT phosphorylation, retinoblastoma tumor suppressor (Rb), phosphorylated Rb, Cyclin D1 | |
| Gene or Protein evidence | Gomisin G did not induce apoptosis but drastically inhibited AKT phosphorylation and reduced the amount of retinoblastoma tumor suppressor protein (Rb) and phosphorylated Rb. Gomisin G induced in a proteasome-dependent manner a decrease in Cyclin D1. | |
| Target pathways | NA | |
| IC50 | NA | |
| Potency | Treatment with Gomisin G suppressed the viability of two TNBC cell lines, MDA-MB-231 and MDA-MB-468 but not non-TNBC cell lines such as MCF-7, T47D, and ZR75-1. | |
| Cell line/ mice model | MDA-MB-231 and MDA-MB-468 | |
| Additional information | These results show that Gomisin G has an anti-cancer activity by suppressing proliferation rather than inducing apoptosis in TNBC cells. Our study suggests that Gomisin G could be used as a therapeutic agent in the treatment of TNBC patients | |
| PubChem ID | 14992067 | |
| Additional PMIDs | NA | |
| Additional sources of information | https://powo.science.kew.org/taxon/urn:lsid:ipni.org:names:60456331-2 | |
| Safety | NA |