| Properties | Information | |
|---|---|---|
| PhytoCAT-ID | PhytoCAT-221 | |
| Phytochemical name or plant extracts | p-hydroxybenzoic acid-4-O-α-d-manopyranosyl-(1 → 3)-α-l-rhamnopyranoside | |
| PMID | 29382154 | |
| Literature evidence | All compounds were shown to inhibit LPS-induced nitric oxide (NO) and prostaglandin E 2 (PGE 2) production by suppressing the expression of inducible NO synthase (iNOS) and cyclooxygenase-2 (COX-2), respectively, in LPS-stimulated RAW 264.7 cells. | |
| IUPAC name | NA | |
| Phytochemicals’ class or type of plant extracts | p-hydroxybenzoic acid glycoside | |
| Source of phytochemicals or plant Extracts | Melilotus officinalis | |
| Geographical availability | Afghanistan, Albania, Altay, Austria, Baleares, Belarus, Bulgaria, Central European Rus, Czechoslovakia, East European Russia, France, Germany, Greece, Gulf States, Hungary, Iran, Iraq, Italy, Kazakhstan, Kirgizstan, Krasnoyarsk, Krym, North Caucasus, Northwest European R, Pakistan, Poland, Romania, Sardegna, South European Russi, Spain, Switzerland, Tadzhikistan, Transcaucasus, Turkey, Turkey-in-Europe, Turkmenistan, Tuva, Ukraine, Uzbekistan, West Himalaya, West Siberia, Yemen, Yugoslavia | |
| Plant parts | Aerial parts | |
| Other cancers | Breast cancer | |
| Target gene or protein | NA | |
| Gene or Protein evidence | NA | |
| Target pathways | NA | |
| IC50 | 4.83 µg/ml against MCF-7 | |
| Potency | compounds 1 and 2 have better antitumor activity compared to other compounds. | |
| Cell line/ mice model | MCF-7 | |
| Additional information | The results showed that compounds 1, 2, 7, 8, 9 exhibited better antioxidant activity compared to the other compounds. compounds 1-9 had different inhibitory effects on the release of NO, TNF-α and IL-6 in LPS-stimulated RAW264. | |
| PubChem ID | NA | |
| Additional PMIDs | NA | |
| Additional sources of information | https://powo.science.kew.org/taxon/urn:lsid:ipni.org:names:30429323-2 | |
| Safety | NA |