| Properties | Information | |
|---|---|---|
| PhytoCAT-ID | PhytoCAT-1633 | |
| Phytochemical name or plant extracts | beta-phenethyl isothiocyanate | |
| PMID | 15337839 | |
| Literature evidence | BITC and PEITC can inhibit the growth of human breast cancer cells as well as human mammary epithelium cells at concentrations similar to those of the chemotherapeutic drug DNM. | |
| IUPAC name | 1-isothiocyanatonaphthalene | |
| Phytochemicals’ class or type of plant extracts | Isothiocyanate | |
| Source of phytochemicals or plant Extracts | Cruciferous vegetables | |
| Geographical availability | NA | |
| Plant parts | NA | |
| Other cancers | Breast cancer | |
| Target gene or protein | NA | |
| Gene or Protein evidence | NA | |
| Target pathways | NA | |
| IC50 | At 1h, 2h, 3h, 6h,48h: 20.4 ± 0.78 μM, 14.0 ± 0.54 μM, 12.8 ± 0.65 μM, 7.56 ± 0.31 μM, 7.32 ± 0.25 μM against MCF-7/Adr respectively 30.3 ± 0.98 μM, 20.8 ± 1.95 μM, 15.2 ± 0.10 μM, 22.6± 3.54 μM, 6.51 ± 0.86 μM against MCF-7/wt respectively | |
| Potency | NA | |
| Cell line/ mice model | MCF-7/Adr, MCF-7/wt | |
| Additional information | The effect of these ITCs on cell growth may contribute to the cancer chemopreventive properties of ITCs by suppressing the growth of preclinical tumors, and may indicate a potential use of these compounds as chemotherapeutic agents in cancer treatment. | |
| PubChem ID | 16741 | |
| Additional PMIDs | NA | |
| Additional sources of information | NA | |
| Safety | NA |