| Properties | Information | |
|---|---|---|
| PhytoCAT-ID | PhytoCAT-1289 | |
| Phytochemical name or plant extracts | Ziziphus jujube extract | |
| PMID | 22301448 | |
| Literature evidence | RESULTS: ZE1, ZE2, and ZE4 exerted significant antiproliferative effects on estrogen receptor alpha (ERα) positive MCF-7 (IC(50) values of 14.42, 7.64, 1.69μg/mL) and ERα negative SKBR3 (IC(50) values of 14.06, 6.21, 3.70μg/mL) human breast cancer cells. | |
| IUPAC name | NA | |
| Phytochemicals’ class or type of plant extracts | extract | |
| Source of phytochemicals or plant Extracts | Ziziphus jujube | |
| Geographical availability | China North-Central, China Southeast, Inner Mongolia, Korea, Manchuria, Xinjiang | |
| Plant parts | Fruits | |
| Other cancers | Breast cancer, Cervical cancer | |
| Target gene or protein | Bax, Bad, Bid | |
| Gene or Protein evidence | We found an increase in the levels of Bax, Bad and Bid expression as well as the enhancement of proteolytic form of PARP (89 kDa) in MCF-7 and SKBR3 breast cancer cells upon Ziziphus jujube extracts treatments compared to the control | |
| Target pathways | NA | |
| IC50 | 14.42 µg/mL (ZE1) , 7.64 µg/mL (ZE2), 1.69 µg/mL (ZE4) against MCF-7 14.06µg/mL (ZE1) , 6.21 µg/mL (ZE2), 3.70µg/Ml (ZE4) against SKBR-3 | |
| Potency | In the present study we have investigated the potential antiproliferative activity of Ziziphus jujube fruit extracts on estrogen receptor alpha (ER) positive MCF-7 and ER negative SKBR3 human breast cancer cells | |
| Cell line/ mice model | MCF-7, SKBR-3, OV2008 | |
| Additional information | Induces cell death by apoptosis in both malignant breast cells Enhances expression of Bax and decreases Bcl2 gene leading to apoptosis (MCF-7 and OV2008) | |
| PubChem ID | NA | |
| Additional PMIDs | 27222827 | |
| Additional sources of information | https://powo.science.kew.org/taxon/urn:lsid:ipni.org:names:719213-1 | |
| Safety | NA |