| Properties | Information | |
|---|---|---|
| PhytoCAT-ID | PhytoCAT-1913 | |
| Phytochemical name or plant extracts | Ziyang green tea (ZTP) | |
| PMID | 28911558 | |
| Literature evidence | This is the first report showing that ZTP is a potential novel dietary agent for cancer chemoprevention or chemotherapy. | |
| IUPAC name | NA | |
| Phytochemicals’ class or type of plant extracts | Ethanolic extract | |
| Source of phytochemicals or plant Extracts | Ziyang green tea | |
| Geographical availability | China | |
| Plant parts | Leaves | |
| Other cancers | Breast cancer | |
| Target gene or protein | p53, CDK2, Bax, Bcl-2 , Caspase 3, Caspase 9 | |
| Gene or Protein evidence | Western blotting assay indicated that ZTP induced cell-cycle arrest by upregulation of p53 and reduced the expression of CDK2 in MCF-7 cells. ZTP-caused cell apoptosis was associated with an increase in Bax/Bcl-2 ratio, and activation of caspase-3 and -9. | |
| Target pathways | NA | |
| IC50 | 172.2 μg/mL against MCF-7 | |
| Potency | MCF-7 cells treated with ZTP also showed an overproduction of reactive oxygen species, suggesting that reactive oxygen species played an important role in the induction of apoptosis in MCF-7 cells. | |
| Cell line/ mice model | MCF-7 | |
| Additional information | This is the first report showing that ZTP is a potential novel dietary agent for cancer chemoprevention or chemotherapy. | |
| PubChem ID | NA | |
| Additional PMIDs | NA | |
| Additional sources of information | NA | |
| Safety | NA |