| Properties | Information | |
|---|---|---|
| PhytoCAT-ID | PhytoCAT-846 | |
| Phytochemical name or plant extracts | Zerumbone | |
| PMID | 30396310 | |
| Literature evidence | Zerumbone (2,6,9,9-tetramethylcycloundeca-2,6,10-trien-1-one, ZER), a chemical constituent present in the Zingiber zerumbet is known to exhibit anti-breast cancer activity by modulating several proteins to induce apoptosis. | |
| IUPAC name | (2E,6E,10E)-2,6,9,9-tetramethylcycloundeca-2,6,10-trien-1-one | |
| Phytochemicals’ class or type of plant extracts | Sesquiterpenoid | |
| Source of phytochemicals or plant Extracts | Zingiber zerumbet | |
| Geographical availability | Andaman Is., Assam, Bangladesh, Borneo, Cambodia, China South-Central, China Southeast, East Himalaya, India, Laos, Malaya, Myanmar, Nicobar Is., Philippines, Taiwan, Thailand, Vietnam | |
| Plant parts | NA | |
| Other cancers | Breast cancer | |
| Target gene or protein | Bax, Caspase 7, Caspase 9, Bcl-2 | |
| Gene or Protein evidence | Western blot analysis indicated that zerumbone significantly upregulated BAX, caspase-7, and caspase-9 expression and decreased BCL-2 expression, thereby inducing proapoptotic protein-mediated cell death combined with PTX. | |
| Target pathways | NA | |
| IC50 | NA | |
| Potency | our study demonstrated that zerumbone (15 μM) significantly enhanced ROS when combined with PTX (1 μM) treatment. | |
| Cell line/ mice model | MCF-7 | |
| Additional information | The prooxidant properties of zerumbone potentially resensitize breast cancer cells to PTX by enhancing intracellular ROS-mediated oxidative stress. | |
| PubChem ID | 5470187 | |
| Additional PMIDs | 35240000 35073347 30396310 | |
| Additional sources of information | https://powo.science.kew.org/taxon/urn:lsid:ipni.org:names:798401-1 | |
| Safety | NA |