| Properties | Information | |
|---|---|---|
| PhytoCAT-ID | PhytoCAT-1589 | |
| Phytochemical name or plant extracts | Yanhusuo extract | |
| PMID | 18813823 | |
| Literature evidence | In addition, the yanhusuo extract inhibited the mRNA expression and activity of metalloproteinase-9 (MMP-9). | |
| IUPAC name | NA | |
| Phytochemicals’ class or type of plant extracts | Extract | |
| Source of phytochemicals or plant Extracts | Corydalis yanhusuo | |
| Geographical availability | China South-Central, China Southeast | |
| Plant parts | NA | |
| Other cancers | Breast cancer | |
| Target gene or protein | p38, MMP9 | |
| Gene or Protein evidence | The anti-cancer metastasis effect of yanhusuo involved the activation of p38 and inhibition of ERK1/2 and SAPK/JNK mitogen-activated protein kinase (MAPK) signaling. In addition, the yanhusuo extract inhibited the mRNA expression and activity of metalloproteinase-9 (MMP-9). | |
| Target pathways | ERK1/2 and SAPK/JNK mitogen-activated protein kinase (MAPK) signaling pathway | |
| IC50 | NA | |
| Potency | We found that the yanhusuo extract inhibited the migration and invasion of MDA-MB-231 cells in vitro. | |
| Cell line/ mice model | MDA-MB-231 | |
| Additional information | Our experiments identified the biological activity of yanhusuo against cancer metastasis in vitro and provide a rationale for its further investigation. | |
| PubChem ID | NA | |
| Additional PMIDs | NA | |
| Additional sources of information | https://powo.science.kew.org/taxon/urn:lsid:ipni.org:names:929107-1 | |
| Safety | NA |