| Properties | Information | |
|---|---|---|
| PhytoCAT-ID | PhytoCAT-2167 | |
| Phytochemical name or plant extracts | Xanthotoxol | |
| PMID | 31673107 | |
| Literature evidence | Drug-likeness property was checked by applying the Lipinski's rule of five on the furanocoumarins to evaluate anti-breast cancer activity. | |
| IUPAC name | 9-hydroxyfuro[3,2-g]chromen-7-one | |
| Phytochemicals’ class or type of plant extracts | Furanocoumarin | |
| Source of phytochemicals or plant Extracts | Angelica japonica | |
| Geographical availability | Japan, Korea, Nansei-shoto, Ogasawara-shoto, Taiwan | |
| Plant parts | NA | |
| Other cancers | Breast cancer | |
| Target gene or protein | ERα, PR, EGFR, mTOR | |
| Gene or Protein evidence | The aim of the study has been on certain phytochemicals which has potent actions on ERα, PR, EGFR and mTOR inhibition. | |
| Target pathways | NA | |
| IC50 | NA | |
| Potency | The results confirm that Xanthotoxol has the best docking score for breast cancer followed by Bergapten, Angelicin, Psoralen and Isoimperatorin. Further, the in-vitro results also validate the molecular docking analysis. This study suggests that the selected furanocoumarins can be further investigated and evaluated for breast cancer treatment and management strategies. | |
| Cell line/ mice model | In-silico | |
| Additional information | NA | |
| PubChem ID | 65090 | |
| Additional PMIDs | NA | |
| Additional sources of information | https://powo.science.kew.org/taxon/urn:lsid:ipni.org:names:837659-1 | |
| Safety | NA |