| Properties | Information | |
|---|---|---|
| PhytoCAT-ID | PhytoCAT-841 | |
| Phytochemical name or plant extracts | Xanthorrhizol | |
| PMID | 17201174 | |
| Literature evidence | Author information: (1)Bioassay Unit, Herbal Medicine Research Center, Institute for Medical Research, 50588 Jalan Pahang, Kuala Lumpur, Malaysia. yhcheah@gmail.com Xanthorrhizol is a natural sesquiterpenoid compound isolated from the rhizome of Curcuma xanthorrhiza Roxb (Zingiberaceae). | |
| IUPAC name | 2-methyl-5-[(2R)-6-methylhept-5-en-2-yl]phenol | |
| Phytochemicals’ class or type of plant extracts | Sesquiterpenoid | |
| Source of phytochemicals or plant Extracts | Curcuma xanthorrhiza | |
| Geographical availability | India | |
| Plant parts | Rhizome | |
| Other cancers | Breast cancer | |
| Target gene or protein | Bcl-2, p53, PARP-1, pS2 | |
| Gene or Protein evidence | These results, thereby, suggest that xanthorrhizol has antiproliferative effects on MCF-7 cells by inducing apoptosis through the modulation of bcl-2, p53 and PARP-1 protein levels. Xanthorrhizol also significantly enhanced the expression of the pS2 gene in MCF-7 cells. | |
| Target pathways | Mitochondria-mediated pathway | |
| IC50 | 8.67 +/- 0.79 μg/ml against MDA-MB-231 | |
| Potency | An antiproliferation assay using the MTT method indicated that xanthorrhizol inhibited the proliferation of the human breast cancer cell line, MCF-7, with an EC50 value of 1.71 microg/ml. | |
| Cell line/ mice model | MDA-MB-231 and MCF-7 | |
| Additional information | Treatment with xanthorrhizol caused 50% growth inhibition on MDA-MB-231 cells at 8.67 +/- 0.79 microg/ml as determined by sulforhodamine B (SRB) assay. | |
| PubChem ID | 93135 | |
| Additional PMIDs | 19881304 33683188 21772753 21232161 17201174 19189649 19118501 | |
| Additional sources of information | https://powo.science.kew.org/taxon/urn:lsid:ipni.org:names:796485-1 | |
| Safety | NA |